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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SAMD3  -  sterile alpha motif domain containing 3

Homo sapiens

Synonyms: FLJ34032, SAM domain-containing protein 3, Sterile alpha motif domain-containing protein 3, bA73O6.2
 
 
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High impact information on SAMD3

  • The expression of TGF beta1, Smad2, and Samd3 and their phosphorylated protein forms, and cell cycle inhibitors, p15(Ink4b) and p21(Cip1), was lower during the proliferative phase but higher during the differentiation phase [1].
  • Quantitative reverse transcription-PCR analysis showed complete loss of expression of two genes located at 6q23.1, AK091351 (hypothetical protein FLJ34032) and KIAA1913, in the cell line DAOY. mRNA levels of these genes was reduced in cell lines D283 and D384, and in 50% and 70% of primary tumors, respectively [2].

References

  1. Trans-differentiation of Alveolar Epithelial Type II Cells to Type I Cells Involves Autocrine Signaling by Transforming Growth Factor beta1 through the Smad Pathway. Bhaskaran, M., Kolliputi, N., Wang, Y., Gou, D., Chintagari, N.R., Liu, L. J. Biol. Chem. (2007) [Pubmed]
  2. Identification of a novel homozygous deletion region at 6q23.1 in medulloblastomas using high-resolution array comparative genomic hybridization analysis. Hui, A.B., Takano, H., Lo, K.W., Kuo, W.L., Lam, C.N., Tong, C.Y., Chang, Q., Gray, J.W., Ng, H.K. Clin. Cancer Res. (2005) [Pubmed]
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