Gene Review:
CYP2A7P1 - cytochrome P450, family 2, subfamily A,...
Homo sapiens
Synonyms:
CYP2A18PC, CYP2A18PN, CYP2A7P2, CYP2A7PT
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Disease relevance of CYP2A7P1
- The same structure was also detected in a bacteriophage P1 clone, which contained a full-length CYP2GP1 gene, exons 6 through 9 of CYP2A7P2, and the CYP2B7 gene [1].
High impact information on CYP2A7P1
- A genomic fragment comprising exons 7 through 9 of CYP2GP1 and exons 6 through 9 of a previously unidentified CYP2A gene, designated CYP2A7P2, was isolated from an EMBL3 library; the two genes were arranged in outward opposite directions with about 8 kbp of intervening sequence [1].
- These results indicate that CYP2A7P2 is located near CYP2B7 in the middle of the CYP2A-2B-2F gene cluster on chromosome 19 [1].
Analytical, diagnostic and therapeutic context of CYP2A7P1
- Furthermore, an analysis of CYP2A sequence alignment suggests that CYP2A7P2 may be derived from the same ancestral gene that gave rise to CYP2A7P1, which was corrupted by a large insertion at intron 5 [1].
References
- Identification of a new human CYP2A gene fragment with close linkage to CYP2GP1. Sheng, J., Hua, Z., Guo, J., Caggana, M., Ding, X. Drug Metab. Dispos. (2001) [Pubmed]
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