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Gene Review:

CYP2G1P - cytochrome P450, family 2, subfamily G,...

Homo sapiens

Synonyms: CYP2G1, CYP2G2P, CYP2GP1, Cytochrome P450 2G1 pseudogene

Zhuo, X. et al., Sheng, J. et al., Ling, G. et al., Sheng, J. et al., Sheng, J. et al., et al.

Genter, Liang, Gu, Ding, Negishi, McKinnon, Nebert,

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High impact information on CYP2G1P

CYP2GP1 contained a single nucleotide deletion in exon 2 (deltaC) and a 2.4-kb deletion between exons 3 and 7 (deltaE4-6), whereas CYP2GP2 contained a nonsense mutation in exon 1 and another in exon 3 [1].
Kinetic analysis and immunoinhibition studies indicated that the OM-specific CYP2G1 plays the major role in metabolic activation of coumarin [2].
We also found that both CYP2A5 and CYP2G1 are inhibitable by DAS in vitro [3].
A genomic fragment comprising exons 7 through 9 of CYP2GP1 and exons 6 through 9 of a previously unidentified CYP2A gene, designated CYP2A7P2, was isolated from an EMBL3 library; the two genes were arranged in outward opposite directions with about 8 kbp of intervening sequence [4].
One fragment, termed E7, which contained an open reading frame for 44 amino acids, is highly homologous in deduced amino acid sequence to residues 322-375 in rabbit or rat CYP2G1 [5].

Biological context of CYP2G1P

In addition to a tissue-selective, abundant expression of CYP1A2, CYP2A, and CYP2G1, some of the OM CYPs are also known to have an early developmental expression, a resistance to xenobiotic inducers, and a lack of responsiveness to circadian rhythm [6].

References

Characterization of human CYP2G genes: widespread loss-of-function mutations and genetic polymorphism. Sheng, J., Guo, J., Hua, Z., Caggana, M., Ding, X. Pharmacogenetics (2000) [Pubmed]
Biotransformation of coumarin by rodent and human cytochromes P-450: metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice. Zhuo, X., Gu, J., Zhang, Q.Y., Spink, D.C., Kaminsky, L.S., Ding, X. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse. Genter, M.B., Liang, H.C., Gu, J., Ding, X., Negishi, M., McKinnon, R.A., Nebert, D.W. Biochem. Pharmacol. (1998) [Pubmed]
Identification of a new human CYP2A gene fragment with close linkage to CYP2GP1. Sheng, J., Hua, Z., Guo, J., Caggana, M., Ding, X. Drug Metab. Dispos. (2001) [Pubmed]
Identification of human genes related to olfactory-specific CYP2G1. Sheng, J., Ding, X. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
Regulation of cytochrome P450 gene expression in the olfactory mucosa. Ling, G., Gu, J., Genter, M.B., Zhuo, X., Ding, X. Chem. Biol. Interact. (2004) [Pubmed]

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