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Gene Review

CYP2G1P  -  cytochrome P450, family 2, subfamily G,...

Homo sapiens

Synonyms: CYP2G1, CYP2G2P, CYP2GP1, Cytochrome P450 2G1 pseudogene
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High impact information on CYP2G1P

  • CYP2GP1 contained a single nucleotide deletion in exon 2 (deltaC) and a 2.4-kb deletion between exons 3 and 7 (deltaE4-6), whereas CYP2GP2 contained a nonsense mutation in exon 1 and another in exon 3 [1].
  • Kinetic analysis and immunoinhibition studies indicated that the OM-specific CYP2G1 plays the major role in metabolic activation of coumarin [2].
  • We also found that both CYP2A5 and CYP2G1 are inhibitable by DAS in vitro [3].
  • A genomic fragment comprising exons 7 through 9 of CYP2GP1 and exons 6 through 9 of a previously unidentified CYP2A gene, designated CYP2A7P2, was isolated from an EMBL3 library; the two genes were arranged in outward opposite directions with about 8 kbp of intervening sequence [4].
  • One fragment, termed E7, which contained an open reading frame for 44 amino acids, is highly homologous in deduced amino acid sequence to residues 322-375 in rabbit or rat CYP2G1 [5].

Biological context of CYP2G1P

  • In addition to a tissue-selective, abundant expression of CYP1A2, CYP2A, and CYP2G1, some of the OM CYPs are also known to have an early developmental expression, a resistance to xenobiotic inducers, and a lack of responsiveness to circadian rhythm [6].


  1. Characterization of human CYP2G genes: widespread loss-of-function mutations and genetic polymorphism. Sheng, J., Guo, J., Hua, Z., Caggana, M., Ding, X. Pharmacogenetics (2000) [Pubmed]
  2. Biotransformation of coumarin by rodent and human cytochromes P-450: metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice. Zhuo, X., Gu, J., Zhang, Q.Y., Spink, D.C., Kaminsky, L.S., Ding, X. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  3. Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse. Genter, M.B., Liang, H.C., Gu, J., Ding, X., Negishi, M., McKinnon, R.A., Nebert, D.W. Biochem. Pharmacol. (1998) [Pubmed]
  4. Identification of a new human CYP2A gene fragment with close linkage to CYP2GP1. Sheng, J., Hua, Z., Guo, J., Caggana, M., Ding, X. Drug Metab. Dispos. (2001) [Pubmed]
  5. Identification of human genes related to olfactory-specific CYP2G1. Sheng, J., Ding, X. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  6. Regulation of cytochrome P450 gene expression in the olfactory mucosa. Ling, G., Gu, J., Genter, M.B., Zhuo, X., Ding, X. Chem. Biol. Interact. (2004) [Pubmed]
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