Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

hsh - hind shaker

Mus musculus

Vouyiouklis, D.A. et al., King, H. et al., Karim, S.A. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on hsh

A physical map of the genomic region on mouse chromosome 3 containing the hindshaker (hsh) mutation [1].
We found that hsh is flanked between D3Mit187 proximally and S100a4 distally [2].
Identification of the hsh mutation will aid our understanding of processes important in regional control of oligodendrocyte development and myelination [2].
Heterozygotes are phenotypically normal, and the hsh mutation shows considerable variation in penetrance and expression depending on genetic background, indicating the influence of modifying loci [2].
We describe the genomic mapping of the hsh mutation to within a 1.2-cM region near the centromere of mouse chromosome 3 [2].

Anatomical context of hsh

Hindshaker (hsh) is a novel, spontaneous, autosomal recessive mouse mutation displaying a myelin deficit, predominantly in the spinal cord [2].
The hsh mutation appears to delay the maturation of oligodendrocytes, particularly in the spinal cord [3].

References

A physical map of the genomic region on mouse chromosome 3 containing the hindshaker (hsh) mutation. Karim, S.A., Johnson, K.J., Griffiths, I.R., Vouyiouklis, D.A. Genomics (2004) [Pubmed]
Mapping of the dysmyelinating murine Hindshaker mutation to a 1.2-cM interval on chromosome 3. Vouyiouklis, D.A., Anderson, T.J., King, H.E., Kirkham, D., Karim, S.A., Johnson, K.J., Griffiths, I.R. Genomics (2002) [Pubmed]
Hindshaker, a novel myelin mutant showing hypomyelination preferentially affecting the spinal cord. King, H., McCulloch, M.C., Barrie, J.A., Kyriakides, E., Beechey, C.V., Cattanach, B.M., Griffiths, I.R. J. Neurocytol. (1997) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.