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Gene Review

Cldn16  -  claudin 16

Rattus norvegicus

Synonyms: Claudin-16, Paracellin-1
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High impact information on Cldn16


Analytical, diagnostic and therapeutic context of Cldn16

  • Immunofluorescent studies of renal sections showed significant increase in calbindin-D28k (238 +/- 10%) and TRPV5 (211 +/- 10%), but no changes in paracellin-1 in Western blotting (cortex: 110 +/- 7%; medulla: 99 +/- 7%) [2].


  1. Association of paracellin-1 with ZO-1 augments the reabsorption of divalent cations in renal epithelial cells. Ikari, A., Hirai, N., Shiroma, M., Harada, H., Sakai, H., Hayashi, H., Suzuki, Y., Degawa, M., Takagi, K. J. Biol. Chem. (2004) [Pubmed]
  2. Increased renal calcium and magnesium transporter abundance in streptozotocin-induced diabetes mellitus. Lee, C.T., Lien, Y.H., Lai, L.W., Chen, J.B., Lin, C.R., Chen, H.C. Kidney Int. (2006) [Pubmed]
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