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Gene Review

CLDN16  -  claudin 16

Bos taurus

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Disease relevance of CLDN16


High impact information on CLDN16

  • Focusing on chicken due to its expression of two galectins as a model for this approach, the combining-site architecture of the lectin from adult liver (CL-16) is apparently homologous to that previously observed for bovine galectin-1 (Solís, D., Jiménez-Barbero, J., Martín-Lomas, M., and Díaz-Mauriño, T. (1994) Eur. J. Biochem. 223, 107-114) [3].
  • These results showed that the carrier rate of F11 deficiency was high in Japanese Black cattle, and that the CL-16 deficiency, hypogenesis syndrome, neonatal weak calf syndrome, and dams groups had a large amount of recessive homozygous genotype than the other groups [4].
  • Abnormal development of nephrons in claudin-16-defective Japanese black cattle [5].
  • Here, we report a multiplex-PCR procedure to determine the genotype for claudin-16 deficiency in preimplantation embryos [2].

Anatomical context of CLDN16


Analytical, diagnostic and therapeutic context of CLDN16

  • When biopsied embryo cells were examined for claudin-16 deficiency, 97.2% of genotypes were consistent with the PCR results obtained for the corresponding embryos [2].


  1. Null mutation of PCLN-1/Claudin-16 results in bovine chronic interstitial nephritis. Hirano, T., Kobayashi, N., Itoh, T., Takasuga, A., Nakamaru, T., Hirotsune, S., Sugimoto, Y. Genome Res. (2000) [Pubmed]
  2. Genetic diagnosis of claudin-16 deficiency and sex determination in bovine preimplantation embryos. Hirayama, H., Kageyama, S., Moriyasu, S., Hirano, T., Sugimoto, Y., Kobayashi, N., Inaba, M., Sawai, K., Onoe, S., Minamihashi, A. J. Reprod. Dev. (2004) [Pubmed]
  3. Different architecture of the combining site of the two chicken galectins revealed by chemical mapping studies with synthetic ligand derivatives. Solís, D., Romero, A., Kaltner, H., Gabius, H.J., Díaz-Mauriño, T. J. Biol. Chem. (1996) [Pubmed]
  4. Carrier Rate of Factor XI Deficiency in Stunted Japanese Black Cattle. Watanabe, D., Hirano, T., Sugimoto, Y., Ogata, Y., Abe, S., Ando, T., Ohtsuka, H., Kunieda, T., Kawamura, S. J. Vet. Med. Sci. (2006) [Pubmed]
  5. Abnormal development of nephrons in claudin-16-defective Japanese black cattle. Okada, K., Ishikawa, N., Fujimori, K., Goryo, M., Ikeda, M., Sasaki, J., Watanabe, D., Takasuga, A., Hirano, T., Sugimoto, Y. J. Vet. Med. Sci. (2005) [Pubmed]
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