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Gene Review

Cldn16  -  claudin 16

Mus musculus

Synonyms: Claudin-16, PCLN1, Paracellin-1, claudin-16, paracellin-1
 
 
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Disease relevance of Cldn16

 

High impact information on Cldn16

  • Thus, PCLN-1 localizes to the tight junction followed by association with ZO-1, and the PCLN-1.ZO-1 complex may play an essential role in the reabsorption of divalent cations in renal epithelial cells [2].
  • However, mutants of the deletion (Delta TRV) and the alanine substitution (ARV and TRA) inhibited the association of PCLN-1 with ZO-1 [2].
  • ZO-1 was co-immunoprecipitated with the wild-type PCLN-1 and the alanine substitution (TAV) mutant [2].
  • In vitro binding analysis using glutathione S-transferase fusion protein showed that the C-terminal TRV sequence, especially Thr and Val residues, of PCLN-1 interacts with ZO-1 [2].
  • We hypothesize that CsA reduces the expression and function of paracellin-1 and accounts for the observed renal Mg(2+) wasting [3].
 

Anatomical context of Cldn16

  • Claudin-16 is one of the tight junction protein claudins and has been shown to contribute to reabsorption of divalent cations in the human kidney [4].
  • Restricted localization of claudin-16 at the tight junction in the thick ascending limb of henle's loop together with claudins 3, 4, and 10 in bovine nephrons [4].
  • The cultured cells expressed paracellin-1 and the characteristics of cTAL cells [3].
 

Associations of Cldn16 with chemical compounds

  • Ciclosporin reduces paracellin-1 expression and magnesium transport in thick ascending limb cells [3].
 

Analytical, diagnostic and therapeutic context of Cldn16

  • As the first step to clarify these roles, we examined the expression and distribution of claudin-16 and several other major claudin subtypes, claudins 1-4 and 10, in bovine renal tubular segments by immunofluorescence microscopy [4].
  • Real-time PCR and western blotting were used to test the CsA effects on paracellin-1 expression of cultured cTAL cells [3].

References

  1. Transgenic RNAi depletion of claudin-16 and the renal handling of magnesium. Hou, J., Shan, Q., Wang, T., Gomes, A.S., Yan, Q., Paul, D.L., Bleich, M., Goodenough, D.A. J. Biol. Chem. (2007) [Pubmed]
  2. Association of paracellin-1 with ZO-1 augments the reabsorption of divalent cations in renal epithelial cells. Ikari, A., Hirai, N., Shiroma, M., Harada, H., Sakai, H., Hayashi, H., Suzuki, Y., Degawa, M., Takagi, K. J. Biol. Chem. (2004) [Pubmed]
  3. Ciclosporin reduces paracellin-1 expression and magnesium transport in thick ascending limb cells. Chang, C.T., Hung, C.C., Tian, Y.C., Yang, C.W., Wu, M.S. Nephrol. Dial. Transplant. (2007) [Pubmed]
  4. Restricted localization of claudin-16 at the tight junction in the thick ascending limb of henle's loop together with claudins 3, 4, and 10 in bovine nephrons. Ohta, H., Adachi, H., Takiguchi, M., Inaba, M. J. Vet. Med. Sci. (2006) [Pubmed]
 
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