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Gene Review

SLC7A13  -  solute carrier family 7 (anionic amino...

Homo sapiens

Synonyms: AGT-1, AGT1, Sodium-independent aspartate/glutamate transporter 1, Solute carrier family 7 member 13, X-amino acid transporter 2, ...
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High impact information on SLC7A13

  • The cysteine residue responsible for the disulfide bond formation between transporters (light chains) and heavy chain subunits of the heterodimeric amino acid transporter family is conserved for AGT1 [1].
  • This could be related to the fact that mXAT1 and hXAT2 did not form detectable disulphide-linked heterodimers with 4F2hc or rBAT when they were co-expressed in CHO cells [2].
  • The hXAT2 gene is located on chromosome 8q21 [2].

Analytical, diagnostic and therapeutic context of SLC7A13

  • We report the molecular cloning and tissue expression of new mouse and human homologues of the LAT family, termed mXAT1, mXAT2 and hXAT2 [2].


  1. Identification of a novel Na+-independent acidic amino acid transporter with structural similarity to the member of a heterodimeric amino acid transporter family associated with unknown heavy chains. Matsuo, H., Kanai, Y., Kim, J.Y., Chairoungdua, A., Kim, d.o. .K., Inatomi, J., Shigeta, Y., Ishimine, H., Chaekuntode, S., Tachampa, K., Choi, H.W., Babu, E., Fukuda, J., Endou, H. J. Biol. Chem. (2002) [Pubmed]
  2. Homologues of amino acid permeases: cloning and tissue expression of XAT1 and XAT2. Blondeau, J.P. Gene (2002) [Pubmed]
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