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Gene Review:

Kcnj16 - potassium inwardly-rectifying channel,...

Mus musculus

Synonyms: 6430410F18Rik, AI132396, Inward rectifier K(+) channel Kir5.1, Inward rectifier potassium channel 16, Kir5.1, ...

Hibino, H. et al., Liu, Y. et al., Mouri, T. et al., Lourdel, S. et al.

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Disease relevance of Kcnj16

These suggest that human Kir5.1 may be involved in the regulation of fluid and pH balance, thus making it a potential therapeutic target for hypertension, renal failure, or pancreatic disease [1].

High impact information on Kcnj16

Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes [2].
Kir4.1, Kir4.2 and Kir5.1 mRNAs were all detected in the DCT [3].
Assignment of mouse inwardly rectifying potassium channel Kcnj16 to the distal region of mouse chromosome 11 [4].

Other interactions of Kcnj16

1. Immunolabeling using specific antibodies showed that channels comprising Kir4.1 and Kir5.1 subunits were assembled in a region-specific fashion [2].

References

The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas. Liu, Y., McKenna, E., Figueroa, D.J., Blevins, R., Austin, C.P., Bennett, P.B., Swanson, R. Cytogenet. Cell Genet. (2000) [Pubmed]
Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes. Hibino, H., Fujita, A., Iwai, K., Yamada, M., Kurachi, Y. J. Biol. Chem. (2004) [Pubmed]
An inward rectifier K(+) channel at the basolateral membrane of the mouse distal convoluted tubule: similarities with Kir4-Kir5.1 heteromeric channels. Lourdel, S., Paulais, M., Cluzeaud, F., Bens, M., Tanemoto, M., Kurachi, Y., Vandewalle, A., Teulon, J. J. Physiol. (Lond.) (2002) [Pubmed]
Assignment of mouse inwardly rectifying potassium channel Kcnj16 to the distal region of mouse chromosome 11. Mouri, T., Kittaka, N., Horio, Y., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Kurachi, Y. Genomics (1998) [Pubmed]

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