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Gene Review

meis1b  -  Meis homeobox 1 b

Danio rerio

Synonyms: SO:0000704, cb224, id:ibd5078, meis1, meis1.1, ...
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High impact information on meis1

  • Here we report that reducing meis function transforms the caudal hindbrain to an r4-like fate, and we exploit this experimental state to explore how r4 versus r5-r6 segments are set aside [1].

Anatomical context of meis1

  • In the hindbrain, the absence of either form of PACAP had little effect, as shown by expression of ephA4 and meis1 [2].

Regulatory relationships of meis1


  1. Paralog group 1 hox genes regulate rhombomere 5/6 expression of vhnf1, a repressor of rostral hindbrain fates, in a meis-dependent manner. Choe, S.K., Sagerström, C.G. Dev. Biol. (2004) [Pubmed]
  2. Role of two genes encoding PACAP in early brain development in zebrafish. Wu, S., Adams, B.A., Fradinger, E.A., Sherwood, N.M. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  3. meis1 regulates cyclin D1 and c-myc expression, and controls the proliferation of the multipotent cells in the early developing zebrafish eye. Bessa, J., Tavares, M.J., Santos, J., Kikuta, H., Laplante, M., Becker, T.S., Gómez-Skarmeta, J.L., Casares, F. Development (2008) [Pubmed]
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