Disease relevance of myca

• Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia [1].

High impact information on myca

• Zebra fish myc family and max genes: differential expression and oncogenic activity throughout vertebrate evolution [2].
• To gain insight into the role of Myc family oncoproteins and their associated protein Max in vertebrate growth and development, we sought to identify homologs in the zebra fish (Brachydanio rerio) [2].
• Fibroblasts transfected with myc-tagged Nkx2.5 express cardiac genes [3].
• Esrom has recently been identified as an ortholog of PAM (protein associated with c-myc), a very large protein involved in synaptogenesis in Drosophila and C. elegans [4].
• Of interest, the expression of cyclin genes (A2, B, D1, and E), hepatocyte nuclear factor genes (HNF-1alpha, beta, -3beta, and 4alpha), and oncogenic markers (P53, c-myc, beta-catenin, N-ras, and gankyrin) were up-regulated, while the expression of C/EBP-alpha was down-regulated in a zfMcl-1a-mediated anti-apoptotic process of the liver [5].

Biological context of myca

• The nt sequence homologous to c-myc exon 1 of higher vertebrates has not been found [6].
• Both genes contain two coding exons which are homologs of c-myc exons 2 and 3 in higher vertebrates [6].
• Our results suggest that phosphorylation might be a conserved post-translational modification that allows CNBP to perform a fine tune expression regulation of a group of target genes, including c-myc, during vertebrate embryogenesis [7].
• Instead, it promotes in vitro the annealing of complementary oligonucleotides representing the CT element (CCCTCCCC) from the human cellular myelocytomatosis oncogene (c-myc) promoter, an element responsible for c-myc enhancer transcription [7].

Anatomical context of myca

• We also expressed a construct of salmon myc-tagged SR-BI in salmon TO cells and HeLa cells, which gave a protein of approximately 80 kDa on reducing SDS-PAGE using an antibody against the myc-epitope [8].

Associations of myca with chemical compounds

• Esrom, an ortholog of PAM (protein associated with c-myc), regulates pteridine synthesis in the zebrafish [4].
• Receptor-encoding cDNA cloned into this vector was expressed as a fusion protein with the N-terminal membrane import sequence of the guinea-pig serotonin receptor followed by a myc tag [9].

References