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Gene Review

ccnd1  -  cyclin D1

Danio rerio

Synonyms: G1/S-specific cyclin-D1, SO:0000704, cb161, cycd1, etID37810.7, ...
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Disease relevance of ccnd1


High impact information on ccnd1


Biological context of ccnd1


Associations of ccnd1 with chemical compounds

  • Cyclin D1-deficient embryos had virtually identical IR sensitivity profiles when compared with embryos treated with flavopiridol [2].

Analytical, diagnostic and therapeutic context of ccnd1

  • To investigate the regulation of this process further, the translation of ccnd1 mRNA, a G1/S checkpoint control element, was impaired by microinjection of ccnd1-specific morpholino phosphorodiamidate (MO) 20mer or hydroxyprolyl-phosphono peptide nucleic acid (HypNA-pPNA) 16mer antisense oligonucleotides [1].


  1. Coordinate control of cell cycle regulatory genes in zebrafish development tested by cyclin D1 knockdown with morpholino phosphorodiamidates and hydroxyprolyl-phosphono peptide nucleic acids. Duffy, K.T., McAleer, M.F., Davidson, W.R., Kari, L., Kari, C., Liu, C.G., Farber, S.A., Cheng, K.C., Mest, J.R., Wickstrom, E., Dicker, A.P., Rodeck, U. Nucleic Acids Res. (2005) [Pubmed]
  2. Antisense inhibition of cyclin D1 expression is equivalent to flavopiridol for radiosensitization of zebrafish embryos. McAleer, M.F., Duffy, K.T., Davidson, W.R., Kari, G., Dicker, A.P., Rodeck, U., Wickstrom, E. Int. J. Radiat. Oncol. Biol. Phys. (2006) [Pubmed]
  3. Histone deacetylase 1 is required for cell cycle exit and differentiation in the zebrafish retina. Stadler, J.A., Shkumatava, A., Norton, W.H., Rau, M.J., Geisler, R., Fischer, S., Neumann, C.J. Dev. Dyn. (2005) [Pubmed]
  4. Zebrafish cyclin D1 is differentially expressed during early embryogenesis. Yarden, A., Salomon, D., Geiger, B. Biochim. Biophys. Acta (1995) [Pubmed]
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