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Gene Review:

unc-63 - Protein UNC-63

Caenorhabditis elegans

Culetto, E. et al., Hosono, R. et al.

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High impact information on unc-63

Here we describe the molecular and functional characterization of another levamisole-resistant gene, unc-63, encoding a nAChR alpha subunit with a predicted amino acid sequence most similar to that of UNC-38 [1].
The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunit [1].
We have now identified 3 more such genes (unc-63, unc-11 and unc-64) [2].

References

The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunit. Culetto, E., Baylis, H.A., Richmond, J.E., Jones, A.K., Fleming, J.T., Squire, M.D., Lewis, J.A., Sattelle, D.B. J. Biol. Chem. (2004) [Pubmed]
Additional genes which result in an elevation of acetylcholine levels by mutations in Caenorhabditis elegans. Hosono, R., Kamiya, Y. Neurosci. Lett. (1991) [Pubmed]

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AgaP_AGAP002971	Anopheles gambiae str. PEST
chrna2a	Danio rerio
chrna2b	Danio rerio
nAChRbeta2	Drosophila melanogaster

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