The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

nAChRbeta2  -  nicotinic Acetylcholine Receptor beta2

Drosophila melanogaster

Synonyms: Acetylcholine receptor subunit beta-like 2, Acr96Ac, AcrF, CG6798, Dbeta2, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on nAcRbeta-96A

 

Biological context of nAcRbeta-96A

 

Anatomical context of nAcRbeta-96A

 

Associations of nAcRbeta-96A with chemical compounds

  • SBD, a novel structural subunit of the Drosophila nicotinic acetylcholine receptor, shares its genomic localization with two alpha-subunits [14].
  • Neonicotinoids such as the insecticide imidacloprid (IMI) act as agonists at the insect nicotinic acetylcholine receptor (nAChR) [15].
  • Epibatidine showed substantially higher affinity binding to subunit combinations containing neuronal (beta2 or beta4) subunits than it did to combinations containing muscle-type (gamma or delta) subunits [16].
 

Regulatory relationships of nAcRbeta-96A

  • Nondesensitizing ACh-evoked inward currents were observed when D alpha3 was coexpressed with the chick beta2 subunit [5].
 

Other interactions of nAcRbeta-96A

  • The subunits ALS, D(alpha)2 and SBD can be co-purified by alpha-bungarotoxin affinity chromatography [10].
  • Interestingly, the Anopheles orthologues of Dbeta2 and Dbeta3 possess the vicinal cysteines that define alpha subunits [17].
  • Two of the five chimeric subunits, Cfalpha1/Dalpha2 and Cfalpha3/Dalpha2, when co-expressed with rat beta2 in Drosophila S2 cells, showed high-affinity binding of both epibatidine (Kd=1.6+/-0.6 and 0.13+/-0.06nM, respectively), and imidacloprid (Ki=142+/-34 and 28.7+/-2.4nM, respectively) [18].
  • The octamer between segments beta 2 and beta 3 that maintains a specific register between true binding sites was found to have an indirect role in interchain binding by stabilizing neighboring segments [19].

References

  1. Microtubule architecture specified by a beta-tubulin isoform. Raff, E.C., Fackenthal, J.D., Hutchens, J.A., Hoyle, H.D., Turner, F.R. Science (1997) [Pubmed]
  2. Sp1 cooperates with the ets transcription factor, GABP, to activate the CD18 (beta2 leukocyte integrin) promoter. Rosmarin, A.G., Luo, M., Caprio, D.G., Shang, J., Simkevich, C.P. J. Biol. Chem. (1998) [Pubmed]
  3. Complete amino acid sequence of human transforming growth factor type beta 2. Marquardt, H., Lioubin, M.N., Ikeda, T. J. Biol. Chem. (1987) [Pubmed]
  4. Junctional adhesion molecules (JAMs): more molecules with dual functions? Ebnet, K., Suzuki, A., Ohno, S., Vestweber, D. J. Cell. Sci. (2004) [Pubmed]
  5. D alpha3, a new functional alpha subunit of nicotinic acetylcholine receptors from Drosophila. Schulz, R., Sawruk, E., Mülhardt, C., Bertrand, S., Baumann, A., Phannavong, B., Betz, H., Bertrand, D., Gundelfinger, E.D., Schmitt, B. J. Neurochem. (1998) [Pubmed]
  6. Crystal structure of an enhancer of rudimentary homolog (ERH) at 2.1 Angstroms resolution. Arai, R., Kukimoto-Niino, M., Uda-Tochio, H., Morita, S., Uchikubo-Kamo, T., Akasaka, R., Etou, Y., Hayashizaki, Y., Kigawa, T., Terada, T., Shirouzu, M., Yokoyama, S. Protein Sci. (2005) [Pubmed]
  7. Subunit compositions and catalytic properties of proteasomes from developmental temperature- sensitive mutants of Drosophila melanogaster. Covi, J.A., Belote, J.M., Mykles, D.L. Arch. Biochem. Biophys. (1999) [Pubmed]
  8. The beta-tubulin gene family evolution in the Drosophila montium subgroup of the melanogaster species group. Drosopoulou, E., Scouras, Z.G. J. Mol. Evol. (1995) [Pubmed]
  9. Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing. Beil, B., Screaton, G., Stamm, S. DNA Cell Biol. (1997) [Pubmed]
  10. Nicotinic acetylcholine receptors of Drosophila: three subunits encoded by genomically linked genes can co-assemble into the same receptor complex. Chamaon, K., Smalla, K.H., Thomas, U., Gundelfinger, E.D. J. Neurochem. (2002) [Pubmed]
  11. Insect-vertebrate chimeric nicotinic acetylcholine receptors identify a region, loop B to the N-terminus of the Drosophila Dalpha2 subunit, which contributes to neonicotinoid sensitivity. Shimomura, M., Satoh, H., Yokota, M., Ihara, M., Matsuda, K., Sattelle, D.B. Neurosci. Lett. (2005) [Pubmed]
  12. During Drosophila spermatogenesis beta 1, beta 2 and beta 3 tubulin isotypes are cell-type specifically expressed but have the potential to coassemble into the axoneme of transgenic flies. Kaltschmidt, B., Glätzer, K.H., Michiels, F., Leiss, D., Renkawitz-Pohl, R. Eur. J. Cell Biol. (1991) [Pubmed]
  13. Structural analysis of the CD11b gene and phylogenetic analysis of the alpha-integrin gene family demonstrate remarkable conservation of genomic organization and suggest early diversification during evolution. Fleming, J.C., Pahl, H.L., Gonzalez, D.A., Smith, T.F., Tenen, D.G. J. Immunol. (1993) [Pubmed]
  14. SBD, a novel structural subunit of the Drosophila nicotinic acetylcholine receptor, shares its genomic localization with two alpha-subunits. Sawruk, E., Udri, C., Betz, H., Schmitt, B. FEBS Lett. (1990) [Pubmed]
  15. Novel neonicotinoid-agarose affinity column for Drosophila and Musca nicotinic acetylcholine receptors. Tomizawa, M., Latli, B., Casida, J.E. J. Neurochem. (1996) [Pubmed]
  16. The influence of nicotinic receptor subunit composition upon agonist, alpha-bungarotoxin and insecticide (imidacloprid) binding affinity. Lansdell, S.J., Millar, N.S. Neuropharmacology (2000) [Pubmed]
  17. The nicotinic acetylcholine receptor gene family of the malaria mosquito, Anopheles gambiae. Jones, A.K., Grauso, M., Sattelle, D.B. Genomics (2005) [Pubmed]
  18. Molecular characterisation of nicotinic acetylcholine receptor subunits from the cat flea, Ctenocephalides felis (Siphonaptera: Pulicidae). Bass, C., Lansdell, S.J., Millar, N.S., Schroeder, I., Turberg, A., Field, L.M., Williamson, M.S. Insect Biochem. Mol. Biol. (2006) [Pubmed]
  19. Motifs involved in interchain binding at the tail-end of spectrin. Viel, A., Gee, M.S., Tomooka, L., Branton, D. Biochim. Biophys. Acta (1998) [Pubmed]
 
WikiGenes - Universities