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Gene Review

nAChRbeta2  -  nicotinic Acetylcholine Receptor beta2

Drosophila melanogaster

Synonyms: Acetylcholine receptor subunit beta-like 2, Acr96Ac, AcrF, CG6798, Dbeta2, ...
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High impact information on nAcRbeta-96A


Biological context of nAcRbeta-96A


Anatomical context of nAcRbeta-96A


Associations of nAcRbeta-96A with chemical compounds

  • SBD, a novel structural subunit of the Drosophila nicotinic acetylcholine receptor, shares its genomic localization with two alpha-subunits [14].
  • Neonicotinoids such as the insecticide imidacloprid (IMI) act as agonists at the insect nicotinic acetylcholine receptor (nAChR) [15].
  • Epibatidine showed substantially higher affinity binding to subunit combinations containing neuronal (beta2 or beta4) subunits than it did to combinations containing muscle-type (gamma or delta) subunits [16].

Regulatory relationships of nAcRbeta-96A

  • Nondesensitizing ACh-evoked inward currents were observed when D alpha3 was coexpressed with the chick beta2 subunit [5].

Other interactions of nAcRbeta-96A

  • The subunits ALS, D(alpha)2 and SBD can be co-purified by alpha-bungarotoxin affinity chromatography [10].
  • Interestingly, the Anopheles orthologues of Dbeta2 and Dbeta3 possess the vicinal cysteines that define alpha subunits [17].
  • Two of the five chimeric subunits, Cfalpha1/Dalpha2 and Cfalpha3/Dalpha2, when co-expressed with rat beta2 in Drosophila S2 cells, showed high-affinity binding of both epibatidine (Kd=1.6+/-0.6 and 0.13+/-0.06nM, respectively), and imidacloprid (Ki=142+/-34 and 28.7+/-2.4nM, respectively) [18].
  • The octamer between segments beta 2 and beta 3 that maintains a specific register between true binding sites was found to have an indirect role in interchain binding by stabilizing neighboring segments [19].


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  6. Crystal structure of an enhancer of rudimentary homolog (ERH) at 2.1 Angstroms resolution. Arai, R., Kukimoto-Niino, M., Uda-Tochio, H., Morita, S., Uchikubo-Kamo, T., Akasaka, R., Etou, Y., Hayashizaki, Y., Kigawa, T., Terada, T., Shirouzu, M., Yokoyama, S. Protein Sci. (2005) [Pubmed]
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  10. Nicotinic acetylcholine receptors of Drosophila: three subunits encoded by genomically linked genes can co-assemble into the same receptor complex. Chamaon, K., Smalla, K.H., Thomas, U., Gundelfinger, E.D. J. Neurochem. (2002) [Pubmed]
  11. Insect-vertebrate chimeric nicotinic acetylcholine receptors identify a region, loop B to the N-terminus of the Drosophila Dalpha2 subunit, which contributes to neonicotinoid sensitivity. Shimomura, M., Satoh, H., Yokota, M., Ihara, M., Matsuda, K., Sattelle, D.B. Neurosci. Lett. (2005) [Pubmed]
  12. During Drosophila spermatogenesis beta 1, beta 2 and beta 3 tubulin isotypes are cell-type specifically expressed but have the potential to coassemble into the axoneme of transgenic flies. Kaltschmidt, B., Glätzer, K.H., Michiels, F., Leiss, D., Renkawitz-Pohl, R. Eur. J. Cell Biol. (1991) [Pubmed]
  13. Structural analysis of the CD11b gene and phylogenetic analysis of the alpha-integrin gene family demonstrate remarkable conservation of genomic organization and suggest early diversification during evolution. Fleming, J.C., Pahl, H.L., Gonzalez, D.A., Smith, T.F., Tenen, D.G. J. Immunol. (1993) [Pubmed]
  14. SBD, a novel structural subunit of the Drosophila nicotinic acetylcholine receptor, shares its genomic localization with two alpha-subunits. Sawruk, E., Udri, C., Betz, H., Schmitt, B. FEBS Lett. (1990) [Pubmed]
  15. Novel neonicotinoid-agarose affinity column for Drosophila and Musca nicotinic acetylcholine receptors. Tomizawa, M., Latli, B., Casida, J.E. J. Neurochem. (1996) [Pubmed]
  16. The influence of nicotinic receptor subunit composition upon agonist, alpha-bungarotoxin and insecticide (imidacloprid) binding affinity. Lansdell, S.J., Millar, N.S. Neuropharmacology (2000) [Pubmed]
  17. The nicotinic acetylcholine receptor gene family of the malaria mosquito, Anopheles gambiae. Jones, A.K., Grauso, M., Sattelle, D.B. Genomics (2005) [Pubmed]
  18. Molecular characterisation of nicotinic acetylcholine receptor subunits from the cat flea, Ctenocephalides felis (Siphonaptera: Pulicidae). Bass, C., Lansdell, S.J., Millar, N.S., Schroeder, I., Turberg, A., Field, L.M., Williamson, M.S. Insect Biochem. Mol. Biol. (2006) [Pubmed]
  19. Motifs involved in interchain binding at the tail-end of spectrin. Viel, A., Gee, M.S., Tomooka, L., Branton, D. Biochim. Biophys. Acta (1998) [Pubmed]
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