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Gene Review:

cdc-25.1 - Protein CDC-25.1

Caenorhabditis elegans

Kostić, I. et al., Ashcroft, N.R. et al.

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High impact information on cdc-25.1

This mutant, called rr31, is a fully dominant, maternal-effect, gain-of-function mutation in the cdc-25.1 cell cycle phosphatase that sensitizes the intestinal lineage to an extra cell division [1].
We showed that cdc-25.1 acts at the G1/S transition, as ectopic expression of CDC-25.1 caused entry into S phase in intestinal cells [1].
To examine the expression pattern and function of CDC25 in Caenorhabditis elegans, we characterized a cdc25 homolog, cdc-25.1, during early embryonic development [2].

References

Organ-specific cell division abnormalities caused by mutation in a general cell cycle regulator in C. elegans. Kostić, I., Roy, R. Development (2002) [Pubmed]
RNA-Mediated interference of a cdc25 homolog in Caenorhabditis elegans results in defects in the embryonic cortical membrane, meiosis, and mitosis. Ashcroft, N.R., Srayko, M., Kosinski, M.E., Mains, P.E., Golden, A. Dev. Biol. (1999) [Pubmed]

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