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Gene Review

F57H12.5  -  Protein F57H12.5

Caenorhabditis elegans

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Disease relevance of phosphatase

  • Only one isoform of approximately 35 kDa has been isolated from animals, where it is associated with bone resorption and microbial killing through its phosphatase activity, and hydroxyl radical production, respectively [1].

High impact information on phosphatase

  • A calcineurin phosphatase antagonizes the KIN-29/MEF-2-regulated pathway to modulate levels of CR gene expression [2].
  • Surprisingly, maturation signals then induce CTD phosphorylation that is associated specifically with transcription initiation steps and accumulates to high levels when expression of the CTD phosphatase FCP-1 is inhibited [3].


  1. Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase. Flanagan, J.U., Cassady, A.I., Schenk, G., Guddat, L.W., Hume, D.A. Gene (2006) [Pubmed]
  2. KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC. van der Linden, A.M., Nolan, K.M., Sengupta, P. EMBO J. (2007) [Pubmed]
  3. Transcription reactivation steps stimulated by oocyte maturation in C. elegans. Walker, A.K., Boag, P.R., Blackwell, T.K. Dev. Biol. (2007) [Pubmed]
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