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Gene Review

apr-1  -  Protein APR-1

Caenorhabditis elegans

 
 
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High impact information on apr-1

  • Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos [1].
  • Loss of activity of the APC homolog apr-1 increases the penetrance of this Overinduced phenotype, suggesting that APR-1 may play a negative role in Wnt signaling in this process in C. elegans similar to APC proteins in other systems [2].
  • Second, apr-1 is required for Hox gene expression, most likely by positively regulating the activity of the Wingless signaling pathway [3].
  • First, apr-1 is required for the migration of epithelial cells during morphogenesis of the embryo [3].

References

  1. Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos. Rocheleau, C.E., Downs, W.D., Lin, R., Wittmann, C., Bei, Y., Cha, Y.H., Ali, M., Priess, J.R., Mello, C.C. Cell (1997) [Pubmed]
  2. Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction. Gleason, J.E., Korswagen, H.C., Eisenmann, D.M. Genes Dev. (2002) [Pubmed]
  3. The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression. Hoier, E.F., Mohler, W.A., Kim, S.K., Hajnal, A. Genes Dev. (2000) [Pubmed]
 
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