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Gene Review

rpn-10  -  Protein RPN-10

Caenorhabditis elegans

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Disease relevance of rpn-10

  • The feminization phenotype induced by deletion of the rpn-10 gene was rescued by knockdown of tra-2, one of sexual fate decision genes promoting female development, and its downstream target tra-1, indicating that the TRA-2-mediated sex determination pathway is crucial for the Deltarpn-10-induced sterile phenotype [1].

High impact information on rpn-10

  • We report herein that knockdown of the rpn-10 gene, but not any other proteasome subunit genes, sexually transforms hermaphrodites to females by eliminating hermaphrodite spermatogenesis in Caenorhabditis elegans [1].


  1. Proteasomal Ubiquitin Receptor RPN-10 Controls Sex Determination in Caenorhabditis elegans. Shimada, M., Kanematsu, K., Tanaka, K., Yokosawa, H., Kawahara, H. Mol. Biol. Cell (2006) [Pubmed]
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