Gene Review:
abu-11 - Protein ABU-11
Caenorhabditis elegans
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High impact information on abu-11
- Furthermore, SIR-2.1 normally represses transcription of abu-11 and other ER stress gene family members, indicating that resveratrol extends life span by inhibiting sir-2.1-mediated repression of ER stress genes [1].
- RNA interference of abu-11, a member of this ER stress gene family, abolishes resveratrol-mediated life span extension, and overexpression of abu-11 extends the life span of transgenic animals [1].
References
- A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Viswanathan, M., Kim, S.K., Berdichevsky, A., Guarente, L. Dev. Cell (2005) [Pubmed]
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