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Gene Review:

sir-2.1 - Protein SIR-2.1

Caenorhabditis elegans

Ahmed, S., Viswanathan, M. et al., Lee, G.D. et al., Wang, Y. et al., Tissenbaum, H.A. et al.

Ahmed,

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High impact information on sir-2.1

Genetic analysis indicates that the sir-2.1 transgene functions upstream of daf-16 in the insulin-like signalling pathway [1].
Importantly, analysis with unc-13 mutants indicates that sir-2.1 and daf-16 have overlapping and distinct roles in life span regulation [2].
DD-induced longevity was independent of one C. elegans SIRTUIN, sir-2.1, which is required for the effects of DR, and was independent of the daf-2/insulin-like signaling pathway that independently regulates longevity and larval diapause in C. elegans [3].
These theories were tested in the nematode Caenorhabditis elegans by examining the consequences of eliminating either apoptosis or the daf-16, daf-18 or sir-2.1 genes that promote longevity of postmitotic somatic cells [4].
Furthermore, SIR-2.1 normally represses transcription of abu-11 and other ER stress gene family members, indicating that resveratrol extends life span by inhibiting sir-2.1-mediated repression of ER stress genes [5].

Associations of sir-2.1 with chemical compounds

Treatment of C. elegans with the small molecule resveratrol, however, extends life span in a manner fully dependent upon sir-2.1, but independent of daf-16 [5].

References

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Tissenbaum, H.A., Guarente, L. Nature (2001) [Pubmed]
Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO. Wang, Y., Tissenbaum, H.A. Mech. Ageing Dev. (2006) [Pubmed]
Dietary deprivation extends lifespan in Caenorhabditis elegans. Lee, G.D., Wilson, M.A., Zhu, M., Wolkow, C.A., de Cabo, R., Ingram, D.K., Zou, S. Aging Cell (2006) [Pubmed]
Uncoupling of pathways that promote postmitotic life span and apoptosis from replicative immortality of Caenorhabditis elegans germ cells. Ahmed, S. Aging Cell (2006) [Pubmed]
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Viswanathan, M., Kim, S.K., Berdichevsky, A., Guarente, L. Dev. Cell (2005) [Pubmed]

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