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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Animals, Genetically Modified

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Disease relevance of Animals, Genetically Modified


Psychiatry related information on Animals, Genetically Modified


High impact information on Animals, Genetically Modified

  • When the mafG null mutants were bred to small Maf-overexpressing transgenic animals, both loss- and gain-of-function phenotypes were reversed [11].
  • The 'allelogenic' mouse line we produced carries a hypomorphic allele of Fgf8, which can be converted to a null allele by mating to cre transgenic animals [12].
  • Transgenic animals that express ODR-10 in AWB rather than AWA avoid diacetyl, while maintaining qualitatively normal responses to other attractive and repulsive odorants [13].
  • We have used transgenic animals misexpressing different rhodopsins in the major class of photoreceptor cells to demonstrate that ninaA is required for normal function by two homologous rhodopsins, but not by a less conserved member of the Drosophila rhodopsin gene family [14].
  • Transgenic animals develop hyperkeratosis of the skin and forestomach--the two sites known to express high levels of the keratin 10 polypeptide in vivo [15].

Chemical compound and disease context of Animals, Genetically Modified


Biological context of Animals, Genetically Modified


Anatomical context of Animals, Genetically Modified


Associations of Animals, Genetically Modified with chemical compounds


Gene context of Animals, Genetically Modified

  • In the present study, transgenic animals were immunized with Abeta42, either before the onset of AD-type neuropathologies (at 6 weeks of age) or at an older age (11 months), when amyloid-beta deposition and several of the subsequent neuropathological changes were well established [36].
  • We identify two independent destruction signals in Gli1, D(N) and D(C), and show that removal of these signals stabilizes Gli1 protein and rapidly accelerates tumor formation in transgenic animals [37].
  • In TAP1-deficient, HLA-B27 transgenic animals, HLA-B27 molecules fail to assemble correctly, and do not undergo carbohydrate modifications associated with the Golgi apparatus, such as conversion to Endoglycosidase H resistance, and acquisition of sialic acids [38].
  • The recent observations of tumor formation in Apobec-1 transgenic animals, together with the fact that Apobec-1 is expressed in numerous tissues lacking apo-B, raises the issue of whether this enzyme is essential for a variety of posttranscriptional editing events [39].
  • To accomplish this we generated transgenic animals that carry a Prm1 transgene lacking its normal 3' untranslated region [40].

Analytical, diagnostic and therapeutic context of Animals, Genetically Modified


  1. Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice. Balling, R., Mutter, G., Gruss, P., Kessel, M. Cell (1989) [Pubmed]
  2. Association between the T29-->C polymorphism in the transforming growth factor beta1 gene and breast cancer among elderly white women: The Study of Osteoporotic Fractures. Ziv, E., Cauley, J., Morin, P.A., Saiz, R., Browner, W.S. JAMA (2001) [Pubmed]
  3. RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload. Rogers, J.H., Tamirisa, P., Kovacs, A., Weinheimer, C., Courtois, M., Blumer, K.J., Kelly, D.P., Muslin, A.J. J. Clin. Invest. (1999) [Pubmed]
  4. Oncogenic potential of guanine nucleotide stimulatory factor alpha subunit in thyroid glands of transgenic mice. Michiels, F.M., Caillou, B., Talbot, M., Dessarps-Freichey, F., Maunoury, M.T., Schlumberger, M., Mercken, L., Monier, R., Feunteun, J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  5. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Xie, W., Radominska-Pandya, A., Shi, Y., Simon, C.M., Nelson, M.C., Ong, E.S., Waxman, D.J., Evans, R.M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  6. Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. Keene, C.D., Rodrigues, C.M., Eich, T., Chhabra, M.S., Steer, C.J., Low, W.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  7. Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease. Ferrer, I., Boada Rovira, M., Sánchez Guerra, M.L., Rey, M.J., Costa-Jussá, F. Brain Pathol. (2004) [Pubmed]
  8. Dopaminergic activity in transgenic mice underexpressing glucocorticoid receptors: effect of antidepressants. Cyr, M., Morissette, M., Barden, N., Beaulieu, S., Rochford, J., Di Paolo, T. Neuroscience (2001) [Pubmed]
  9. Spatial navigation in complex and radial mazes in APP23 animals and neurotrophin signaling as a biological marker of early impairment. Hellweg, R., Lohmann, P., Huber, R., Kühl, A., Riepe, M.W. Learn. Mem. (2006) [Pubmed]
  10. Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. Allen, B., Ingram, E., Takao, M., Smith, M.J., Jakes, R., Virdee, K., Yoshida, H., Holzer, M., Craxton, M., Emson, P.C., Atzori, C., Migheli, A., Crowther, R.A., Ghetti, B., Spillantini, M.G., Goedert, M. J. Neurosci. (2002) [Pubmed]
  11. Positive or negative MARE-dependent transcriptional regulation is determined by the abundance of small Maf proteins. Motohashi, H., Katsuoka, F., Shavit, J.A., Engel, J.D., Yamamoto, M. Cell (2000) [Pubmed]
  12. An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Meyers, E.N., Lewandoski, M., Martin, G.R. Nat. Genet. (1998) [Pubmed]
  13. Reprogramming chemotaxis responses: sensory neurons define olfactory preferences in C. elegans. Troemel, E.R., Kimmel, B.E., Bargmann, C.I. Cell (1997) [Pubmed]
  14. The cyclophilin homolog ninaA is a tissue-specific integral membrane protein required for the proper synthesis of a subset of Drosophila rhodopsins. Stamnes, M.A., Shieh, B.H., Chuman, L., Harris, G.L., Zuker, C.S. Cell (1991) [Pubmed]
  15. Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter. Bailleul, B., Surani, M.A., White, S., Barton, S.C., Brown, K., Blessing, M., Jorcano, J., Balmain, A. Cell (1990) [Pubmed]
  16. A new transgenic mouse model of chronic hyperglycemia. Schaefer, E.M., Viard, V., Morin, J., Ferré, P., Pénicaud, L., Ramos, P., Maika, S.D., Ellis, L., Hammer, R.E. Diabetes (1994) [Pubmed]
  17. Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice. Bao, L., Haas, M., Boackle, S.A., Kraus, D.M., Cunningham, P.N., Park, P., Alexander, J.J., Anderson, R.K., Culhane, K., Holers, V.M., Quigg, R.J. J. Immunol. (2002) [Pubmed]
  18. Apo CIII gene transcription is regulated by a cytokine inducible NF-kappa B element. Gruber, P.J., Torres-Rosado, A., Wolak, M.L., Leff, T. Nucleic Acids Res. (1994) [Pubmed]
  19. Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease. Andreassen, O.A., Dedeoglu, A., Ferrante, R.J., Jenkins, B.G., Ferrante, K.L., Thomas, M., Friedlich, A., Browne, S.E., Schilling, G., Borchelt, D.R., Hersch, S.M., Ross, C.A., Beal, M.F. Neurobiol. Dis. (2001) [Pubmed]
  20. Effect of thyroid hormone administration on estrogen-induced sex behavior in female mice. Morgan, M.A., Dellovade, T.L., Pfaff, D.W. Hormones and behavior. (2000) [Pubmed]
  21. Tissue-specific alternative splicing of hybrid Shaker/lacZ genes correlates with kinetic differences in Shaker K+ currents in vivo. Mottes, J.R., Iverson, L.E. Neuron (1995) [Pubmed]
  22. Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene. Alexander, C.M., Howard, E.W., Bissell, M.J., Werb, Z. J. Cell Biol. (1996) [Pubmed]
  23. A family of POU-domain and Pit-1 tissue-specific transcription factors in pituitary and neuroendocrine development. Ingraham, H.A., Albert, V.R., Chen, R.P., Crenshaw 3d, E.B., Elsholtz, H.P., He, X., Kapiloff, M.S., Mangalam, H.J., Swanson, L.W., Treacy, M.N. Annu. Rev. Physiol. (1990) [Pubmed]
  24. Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2. Stevaux, O., Dimova, D., Frolov, M.V., Taylor-Harding, B., Morris, E., Dyson, N. EMBO J. (2002) [Pubmed]
  25. Molecular genetics of acute promyelocytic leukemia. Lin, R.J., Egan, D.A., Evans, R.M. Trends Genet. (1999) [Pubmed]
  26. CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. Herman, A.E., Freeman, G.J., Mathis, D., Benoist, C. J. Exp. Med. (2004) [Pubmed]
  27. Lack of expression of HLA-B27 gene in transgenic mouse trophoblast. Conserved genetic pressures underlying extra-embryonic development. Oudejans, C.B., Krimpenfort, P., Ploegh, H.L., Meijer, C.J. J. Exp. Med. (1989) [Pubmed]
  28. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). Lee, C.G., Homer, R.J., Zhu, Z., Lanone, S., Wang, X., Koteliansky, V., Shipley, J.M., Gotwals, P., Noble, P., Chen, Q., Senior, R.M., Elias, J.A. J. Exp. Med. (2001) [Pubmed]
  29. Interleukin 9-induced in vivo expansion of the B-1 lymphocyte population. Vink, A., Warnier, G., Brombacher, F., Renauld, J.C. J. Exp. Med. (1999) [Pubmed]
  30. Specific neuronal expression of human NGF receptors in the basal forebrain and cerebellum of transgenic mice. Patil, N., Lacy, E., Chao, M.V. Neuron (1990) [Pubmed]
  31. Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes. Anderson, S.J., Levin, S.D., Perlmutter, R.M. Nature (1993) [Pubmed]
  32. Transgenic mice overexpressing the complement inhibitor crry as a soluble protein are protected from antibody-induced glomerular injury. Quigg, R.J., He, C., Lim, A., Berthiaume, D., Alexander, J.J., Kraus, D., Holers, V.M. J. Exp. Med. (1998) [Pubmed]
  33. Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. Lee, J.J., McGarry, M.P., Farmer, S.C., Denzler, K.L., Larson, K.A., Carrigan, P.E., Brenneise, I.E., Horton, M.A., Haczku, A., Gelfand, E.W., Leikauf, G.D., Lee, N.A. J. Exp. Med. (1997) [Pubmed]
  34. Impaired glucose homeostasis in insulin-like growth factor binding protein-1 transgenic mice. Rajkumar, K., Krsek, M., Dheen, S.T., Murphy, L.J. J. Clin. Invest. (1996) [Pubmed]
  35. An interaction between the human cholesteryl ester transfer protein (CETP) and apolipoprotein A-I genes in transgenic mice results in a profound CETP-mediated depression of high density lipoprotein cholesterol levels. Hayek, T., Chajek-Shaul, T., Walsh, A., Agellon, L.B., Moulin, P., Tall, A.R., Breslow, J.L. J. Clin. Invest. (1992) [Pubmed]
  36. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., Kholodenko, D., Lee, M., Liao, Z., Lieberburg, I., Motter, R., Mutter, L., Soriano, F., Shopp, G., Vasquez, N., Vandevert, C., Walker, S., Wogulis, M., Yednock, T., Games, D., Seubert, P. Nature (1999) [Pubmed]
  37. Dual degradation signals control Gli protein stability and tumor formation. Huntzicker, E.G., Estay, I.S., Zhen, H., Lokteva, L.A., Jackson, P.K., Oro, A.E. Genes Dev. (2006) [Pubmed]
  38. Misfolded major histocompatibility complex class I molecules accumulate in an expanded ER-Golgi intermediate compartment. Raposo, G., van Santen, H.M., Leijendekker, R., Geuze, H.J., Ploegh, H.L. J. Cell Biol. (1995) [Pubmed]
  39. Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism. Morrison, J.R., Pászty, C., Stevens, M.E., Hughes, S.D., Forte, T., Scott, J., Rubin, E.M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  40. Premature translation of protamine 1 mRNA causes precocious nuclear condensation and arrests spermatid differentiation in mice. Lee, K., Haugen, H.S., Clegg, C.H., Braun, R.E. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  41. Transcriptional activation by tetracyclines in mammalian cells. Gossen, M., Freundlieb, S., Bender, G., Müller, G., Hillen, W., Bujard, H. Science (1995) [Pubmed]
  42. Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus. Zhang, J., Roschke, V., Baker, K.P., Wang, Z., Alarcón, G.S., Fessler, B.J., Bastian, H., Kimberly, R.P., Zhou, T. J. Immunol. (2001) [Pubmed]
  43. Chronic inflammation and protection from acute hepatitis in transgenic mice expressing TNF in endothelial cells. Willuweit, A., Sass, G., Schöneberg, A., Eisel, U., Tiegs, G., Clauss, M. J. Immunol. (2001) [Pubmed]
  44. Targeting complement in therapy. Kirschfink, M. Immunol. Rev. (2001) [Pubmed]
  45. Transgenic mice over-expressing the human spermidine synthase gene. Kauppinen, L., Myöhänen, S., Halmekytö, M., Alhonen, L., Jänne, J. Biochem. J. (1993) [Pubmed]
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