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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

chs-2  -  Protein CHS-2

Caenorhabditis elegans

 
 
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High impact information on chs-2

  • Chitin deposition in these two sites is likely regulated by the activities of chs-1 (T25G3.2) and chs-2 (F48A11.1), respectively [1].
  • Knocking down chs-2 by RNAi caused a defect in the pharynx and led to L1 larval arrest, indicating that chitin is involved in the development and function of the pharynx [1].
  • C. elegans chitin synthase genes were silenced by feeding nematodes bacteria expressing appropriate chitin synthase dsRNA from a plasmid vector, while M. artiellia egg masses were soaked in dsRNA solution [2].

References

  1. The chitin synthase genes chs-1 and chs-2 are essential for C. elegans development and responsible for chitin deposition in the eggshell and pharynx, respectively. Zhang, Y., Foster, J.M., Nelson, L.S., Ma, D., Carlow, C.K. Dev. Biol. (2005) [Pubmed]
  2. Analysis of chitin synthase function in a plant parasitic nematode, Meloidogyne artiellia, using RNAi. Fanelli, E., Di Vito, M., Jones, J.T., De Giorgi, C. Gene (2005) [Pubmed]
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