Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Y59C2A.1 - Protein Y59C2A.1

Caenorhabditis elegans

Ote, M. et al., Ono, S. et al.

Ono, McGough, Pope, Tolbert, Bui, Pohl, Benian, Gernert, Weeds,

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High impact information on carboxypeptidase

Removal of the C-terminal isoleucine (Ile152) by carboxypeptidase A or truncation by mutagenesis eliminated F-actin binding activity but strongly enhanced actin depolymerizing activity [1].
MF-CPA has amino acid sequence similarities with the proteins in the carboxypeptidase A/B subfamily, from human to nematode [2].
Using microarray analyses, we identified carboxypeptidase A (MF-CPA), which was induced during pupal ecdysis in the wing discs of Bombyx mori [2].

References

The C-terminal tail of UNC-60B (actin depolymerizing factor/cofilin) is critical for maintaining its stable association with F-actin and is implicated in the second actin-binding site. Ono, S., McGough, A., Pope, B.J., Tolbert, V.T., Bui, A., Pohl, J., Benian, G.M., Gernert, K.M., Weeds, A.G. J. Biol. Chem. (2001) [Pubmed]
Identification of molting fluid carboxypeptidase A (MF-CPA) in Bombyx mori. Ote, M., Mita, K., Kawasaki, H., Daimon, T., Kobayashi, M., Shimada, T. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP006206	Anopheles gambiae str. PEST
CG8560	Drosophila melanogaster
CG8562	Drosophila melanogaster
CG18417	Drosophila melanogaster
CG32379	Drosophila melanogaster

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