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Disease relevance of Bombyx


High impact information on Bombyx

  • This effect is specific for 5S RNA genes, since TFIIIA will not form an active template when incubated with a cloned Bombyx mori alanine tRNA gene [6].
  • The messenger RNA for silf fibroin, laveled with 32PO4 and methyl-3H L-methionine, was purified to near homogeneity from the posterior silk gland of the sildworm Bombyx mori, and the sequence of a methylated, RNAase T2-resistant structure was determined [7].
  • 2-Deoxy-alpha-ecdysone from ovaries and eggs of the silkworm, Bombyx mori [8].
  • Recognition of monomeric and polymeric peptidoglycan required different PGRP-LC splice isoforms, while lipid A recognition required an unidentified soluble factor in the hemolymph of Bombyx morii [9].
  • We examined Period (PER) protein regulation in the brain of the silkmoth Antheraea pernyi [10].

Chemical compound and disease context of Bombyx


Biological context of Bombyx


Anatomical context of Bombyx

  • The ATCAT cap site sequence was homologous to a silkmoth chorion PuTCATT cap site sequence, where Pu indicates any purine [21].
  • The Bombyx cad protein was not detected in the ovary and the first 9 hours of eggs, but was first detected evenly during cellular blastoderm stage [20].
  • Differences in PPBP characteristics between nuclear extracts from Sf21 and from Bm5 (Bombyx mori) cell line suggested that additional factors may be involved in the interaction of PPBP with the polyhedrin promoter [22].
  • GTP induces knotting, catenation, and relaxation of DNA by stoichiometric amounts of DNA topoisomerase II from Bombyx mori and HeLa cells [23].
  • The orphan nuclear receptors BmE75 and BmHR3 are induced by 20-hydroxyecdysone in the ovary of the silk moth Bombyx mori at the beginning of pupation and show stage-specific expression in ovarian follicles during pharate adult development [24].

Associations of Bombyx with chemical compounds

  • Structure and in vitro transcription of a glycine tRNA gene from Bombyx mori [25].
  • Biosynthesis of the silkmoth sex pheromone bombykol, (E,Z)-10,12-hexadecadien-1-ol, involves two consecutive desaturation steps, the second of which is unique in that it generates a conjugated diene system from the Delta11-monoene C(16) intermediate [26].
  • Short-labeled 4.5S RNA molecules isolated from the posterior silk gland of Bombyx mori can be separated by two-dimensional polyacrylamide gel electrophoresis into many discrete species, some of which are radiochemically pure by the criteria of RNA fingerprinting [27].
  • In the silkworm Bombyx mori, SG is known to secrete two neuropeptides, diapause hormone (DH) responsible for induction of embryonic diapause and pheromone biosynthesis-activating neuropeptide, which share a pentapeptide amide, Phe-Xaa-Pro-Arg-Leu-NH2 (Xaa = Gly or Ser), at the C terminus [28].
  • Here we show that mulberry leaves are highly toxic to caterpillars other than the silkworm B. mori, because of the ingredients of the latex, a milky sap exuded from mulberry leaf veins [29].

Gene context of Bombyx

  • A cDNA clone encoding MBF1 was isolated from the silkworm Bombyx mori whose sequence predicts a basic protein consisting of 146 amino acids [30].
  • Thus, a complete feedback loop, resembling that found in Drosophila, can be constructed from silkmoth CLOCK, BMAL, PERIOD, and TIMELESS [31].
  • We report here large-scale expression and purification of extracellular domain of the type I receptor for BMP-2/4, using a silkworm expression system [32].
  • To analyze how the silk glands of the lepidopteran, Bombyx mori, develop, we cloned and identified two genes that encode the homeodomain and its flanking regions identical to the corresponding regions of Deformed and Sex combs reduced [33].
  • Evolutionary conservation of the leucine-rich repeat transmembrane protein Gp150 in Drosophila and Bombyx [34].

Analytical, diagnostic and therapeutic context of Bombyx


  1. Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition. Luan, D.D., Korman, M.H., Jakubczak, J.L., Eickbush, T.H. Cell (1993) [Pubmed]
  2. A pattern recognition protein for peptidoglycan. Cloning the cDNA and the gene of the silkworm, Bombyx mori. Ochiai, M., Ashida, M. J. Biol. Chem. (1999) [Pubmed]
  3. DNA superhelicity affects the formation of transcription preinitiation complex on eukaryotic genes differently. Mizutani, M., Ura, K., Hirose, S. Nucleic Acids Res. (1991) [Pubmed]
  4. A cysteine protease encoded by the baculovirus Bombyx mori nuclear polyhedrosis virus. Ohkawa, T., Majima, K., Maeda, S. J. Virol. (1994) [Pubmed]
  5. Cytotoxic activity of Bacillus thuringiensis Cry proteins on mammalian cells transfected with cadherin-like Cry receptor gene of Bombyx mori (silkworm). Tsuda, Y., Nakatani, F., Hashimoto, K., Ikawa, S., Matsuura, C., Fukada, T., Sugimoto, K., Himeno, M. Biochem. J. (2003) [Pubmed]
  6. Assembly of transcriptionally active 5S RNA gene chromatin in vitro. Gottesfeld, J., Bloomer, L.S. Cell (1982) [Pubmed]
  7. The blocked and methylated 5' terminal sequence of a specific cellular messenger: the mRNA for silk fibroin of Bombyx mori. Yang, N.S., Manning, R.F., Gage, L.P. Cell (1976) [Pubmed]
  8. 2-Deoxy-alpha-ecdysone from ovaries and eggs of the silkworm, Bombyx mori. Ohnishi, E., Mizuno, T., Chatani, F., Ikekawa, N., Sakurai, S. Science (1977) [Pubmed]
  9. Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway. Kaneko, T., Goldman, W.E., Mellroth, P., Steiner, H., Fukase, K., Kusumoto, S., Harley, W., Fox, A., Golenbock, D., Silverman, N. Immunity (2004) [Pubmed]
  10. Circadian clock neurons in the silkmoth Antheraea pernyi: novel mechanisms of Period protein regulation. Sauman, I., Reppert, S.M. Neuron (1996) [Pubmed]
  11. A bacterial and silkworm aminoacyl-tRNA synthetase have a common epitope which maps to the catalytic domain of each. Regan, L., Dignam, J.D., Schimmel, P. J. Biol. Chem. (1986) [Pubmed]
  12. Antiviral activity of a serine protease from the digestive juice of Bombyx mori larvae against nucleopolyhedrovirus. Nakazawa, H., Tsuneishi, E., Ponnuvel, K.M., Furukawa, S., Asaoka, A., Tanaka, H., Ishibashi, J., Yamakawa, M. Virology (2004) [Pubmed]
  13. In vitro phagocytosis of Escherichia coli and release of lipopolysaccharide by adhering hemocytes of the silkworm, Bombyx mori. Taniai, K., Wago, H., Yamakawa, M. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  14. An innovative technique for inoculating recombinant baculovirus into the silkworm Bombyx mori using lipofectin. Wu, X., Cao, C., Kumar, V.S., Cui, W. Res. Microbiol. (2004) [Pubmed]
  15. Flufenoxuron, an insect growth regulator, promotes peroral infection by nucleopolyhedrovirus (BmNPV) budded particles in the silkworm, Bombyx mori L. Arakawa, T., Furuta, Y., Miyazawa, M., Kato, M. J. Virol. Methods (2002) [Pubmed]
  16. Regulation of glycine tRNA gene expression in the posterior silk glands of the silkworm Bombyx mori. Taneja, R., Gopalkrishnan, R., Gopinathan, K.P. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  17. Purification and molecular cloning of an inducible gram-negative bacteria-binding protein from the silkworm, Bombyx mori. Lee, W.J., Lee, J.D., Kravchenko, V.V., Ulevitch, R.J., Brey, P.T. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  18. High level transactivation by a modified Bombyx ecdysone receptor in mammalian cells without exogenous retinoid X receptor. Suhr, S.T., Gil, E.B., Senut, M.C., Gage, F.H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  19. Molecular analysis of the deletion mutants in the E homeotic complex of the silkworm Bombyx mori. Ueno, K., Hui, C.C., Fukuta, M., Suzuki, Y. Development (1992) [Pubmed]
  20. A maternal homeobox gene, Bombyx caudal, forms both mRNA and protein concentration gradients spanning anteroposterior axis during gastrulation. Xu, X., Xu, P.X., Suzuki, Y. Development (1994) [Pubmed]
  21. Small gene family encoding an eggshell (chorion) protein of the human parasite Schistosoma mansoni. Bobek, L.A., Rekosh, D.M., LoVerde, P.T. Mol. Cell. Biol. (1988) [Pubmed]
  22. An unusual 30-kDa protein binding to the polyhedrin gene promoter of Autographa californica nuclear polyhedrosis virus. Burma, S., Mukherjee, B., Jain, A., Habib, S., Hasnain, S.E. J. Biol. Chem. (1994) [Pubmed]
  23. GTP induces knotting, catenation, and relaxation of DNA by stoichiometric amounts of DNA topoisomerase II from Bombyx mori and HeLa cells. Hirose, S., Tabuchi, H., Yoshinaga, K. J. Biol. Chem. (1988) [Pubmed]
  24. The BmE75 nuclear receptors function as dominant repressors of the nuclear receptor BmHR3A. Swevers, L., Ito, K., Iatrou, K. J. Biol. Chem. (2002) [Pubmed]
  25. Structure and in vitro transcription of a glycine tRNA gene from Bombyx mori. Fournier, A., Guérin, M.A., Corlet, J., Clarkson, S.G. EMBO J. (1984) [Pubmed]
  26. Involvement of a bifunctional fatty-acyl desaturase in the biosynthesis of the silkmoth, Bombyx mori, sex pheromone. Moto, K., Suzuki, M.G., Hull, J.J., Kurata, R., Takahashi, S., Yamamoto, M., Okano, K., Imai, K., Ando, T., Matsumoto, S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  27. Identification of precursor molecules to individual tRNA species from Bombyx mori. Garber, R.L., Siddiqui, M.A., Altman, S. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  28. Precursor polyprotein for multiple neuropeptides secreted from the suboesophageal ganglion of the silkworm Bombyx mori: characterization of the cDNA encoding the diapause hormone precursor and identification of additional peptides. Sato, Y., Oguchi, M., Menjo, N., Imai, K., Saito, H., Ikeda, M., Isobe, M., Yamashita, O. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  29. Mulberry latex rich in antidiabetic sugar-mimic alkaloids forces dieting on caterpillars. Konno, K., Ono, H., Nakamura, M., Tateishi, K., Hirayama, C., Tamura, Y., Hattori, M., Koyama, A., Kohno, K. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  30. Multiprotein bridging factor 1 (MBF1) is an evolutionarily conserved transcriptional coactivator that connects a regulatory factor and TATA element-binding protein. Takemaru, K., Li, F.Q., Ueda, H., Hirose, S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  31. Constructing a feedback loop with circadian clock molecules from the silkmoth, Antheraea pernyi. Chang, D.C., McWatters, H.G., Williams, J.A., Gotter, A.L., Levine, J.D., Reppert, S.M. J. Biol. Chem. (2003) [Pubmed]
  32. Interaction between soluble type I receptor for bone morphogenetic protein and bone morphogenetic protein-4. Natsume, T., Tomita, S., Iemura, S., Kinto, N., Yamaguchi, A., Ueno, N. J. Biol. Chem. (1997) [Pubmed]
  33. Involvement of the Bombyx Scr gene in development of the embryonic silk gland. Kokubo, H., Ueno, K., Amanai, K., Suzuki, Y. Dev. Biol. (1997) [Pubmed]
  34. Evolutionary conservation of the leucine-rich repeat transmembrane protein Gp150 in Drosophila and Bombyx. Dhulkotia, D., Nguyen, D., Lai, Z.C. Dev. Genes Evol. (2000) [Pubmed]
  35. Molecular cloning of a POU domain-containing factor involved in the regulation of the Bombyx sericin-1 gene. Fukuta, M., Matsuno, K., Hui, C.C., Nagata, T., Takiya, S., Xu, P.X., Ueno, K., Suzuki, Y. J. Biol. Chem. (1993) [Pubmed]
  36. Purification and partial characterization of a lutein-binding protein from the midgut of the silkworm Bombyx mori. Jouni, Z.E., Wells, M.A. J. Biol. Chem. (1996) [Pubmed]
  37. Effect of pH and copper(II) on the conformation transitions of silk fibroin based on EPR, NMR, and Raman spectroscopy. Zong, X.H., Zhou, P., Shao, Z.Z., Chen, S.M., Chen, X., Hu, B.W., Deng, F., Yao, W.H. Biochemistry (2004) [Pubmed]
  38. Quantitative evaluation of the therapeutic effects of antibiotics using silkworms infected with human pathogenic microorganisms. Hamamoto, H., Kurokawa, K., Kaito, C., Kamura, K., Manitra Razanajatovo, I., Kusuhara, H., Santa, T., Sekimizu, K. Antimicrob. Agents Chemother. (2004) [Pubmed]
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