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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

mab-3  -  Protein MAB-3

Caenorhabditis elegans

 
 
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High impact information on mab-3

  • Epistasis analysis is most consistent with a model in which mab-3 is controlled by tra-1, the last switch gene known to act in the somatic sex determination pathway [1].
  • Second, mab-3 activity is required for expression of the male V ray cell lineage [1].
  • Here we find that mab-3 is also required for expression of male-specific genes in sensory neurons of the head and tail and for male interaction with hermaphrodites [2].
  • Mutations in ref-1 restore lin-32::gfp expression and normal V ray development to mab-3 mutants, suggesting that ref-1 is the primary target of MAB-3 in the V ray lineage [3].

References

  1. mab-3, a gene required for sex-specific yolk protein expression and a male-specific lineage in C. elegans. Shen, M.M., Hodgkin, J. Cell (1988) [Pubmed]
  2. Mab-3 is a direct tra-1 target gene regulating diverse aspects of C. elegans male sexual development and behavior. Yi, W., Ross, J.M., Zarkower, D. Development (2000) [Pubmed]
  3. The DM domain protein MAB-3 promotes sex-specific neurogenesis in C. elegans by regulating bHLH proteins. Ross, J.M., Kalis, A.K., Murphy, M.W., Zarkower, D. Dev. Cell (2005) [Pubmed]
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