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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

egl-43  -  Protein EGL-43

Caenorhabditis elegans

 
 
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High impact information on egl-43

  • Migrations of the Caenorhabditis elegans HSNs are regulated by egl-43, a gene encoding two zinc finger proteins [1].
  • We also show that egl-43 function is required for normal development of phasmid neurons, which are sensory neurons located in the tail [1].
  • We computationally identified egl-43 as a gene likely to be expressed in the pre-AC/pre-VU cells and the AC, based on the presence of an enhancer element similar to the one that transcribes lin-3 in the same cells [2].
  • Characterization of the egl-43 regulatory region suggests that EGL-43 is a direct target of LIN-12 and HLH-2 (E12/47), which is required for the specification of the VU fate during AC/VU specification [2].

References

  1. Migrations of the Caenorhabditis elegans HSNs are regulated by egl-43, a gene encoding two zinc finger proteins. Garriga, G., Guenther, C., Horvitz, H.R. Genes Dev. (1993) [Pubmed]
  2. C. elegans EVI1 proto-oncogene, EGL-43, is necessary for Notch-mediated cell fate specification and regulates cell invasion. Hwang, B.J., Meruelo, A.D., Sternberg, P.W. Development (2007) [Pubmed]
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