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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ace-3  -  Protein ACE-3

Caenorhabditis elegans

 
 
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High impact information on ace-3

  • In contrast, ace-1 ace-2 ace-3 triple mutant animals are paralyzed and developmentally arrested; their embryonic development is relatively unimpaired, but they are unable to grow beyond the hatching stage [1].
  • The acetylcholinesterase genes of C. elegans: identification of a third gene (ace-3) and mosaic mapping of a synthetic lethal phenotype [1].
  • Based on the analysis of genetic mosaics, we conclude that in the absence of ace-2 and ace-3 function, the expression of ace-1(+) in muscle cells, but not in neurons, is essential for postembryonic viability [1].
  • The ace-2, ace-3 and ace-4 transcripts were found to be trans-spliced by both SL1 and SL2, although these genes are not included in typical operons [2].
 

Biological context of ace-3

  • This latter gene is expressed in all body-wall and vulval muscle cells (Culetto et al., 1999), whereas ace-2 is expressed almost exclusively in neurons. ace-3 and ace-4 genes are located in close proximity on chromosome II (Combes et al., 2000) [3].

References

  1. The acetylcholinesterase genes of C. elegans: identification of a third gene (ace-3) and mosaic mapping of a synthetic lethal phenotype. Johnson, C.D., Rand, J.B., Herman, R.K., Stern, B.D., Russell, R.L. Neuron (1988) [Pubmed]
  2. Four genes encode acetylcholinesterases in the nematodes Caenorhabditis elegans and Caenorhabditis briggsae. cDNA sequences, genomic structures, mutations and in vivo expression. Combes, D., Fedon, Y., Grauso, M., Toutant, J.P., Arpagaus, M. J. Mol. Biol. (2000) [Pubmed]
  3. Multiple ace genes encoding acetylcholinesterases of Caenorhabditis elegans have distinct tissue expression. Combes, D., Fedon, Y., Toutant, J.P., Arpagaus, M. Eur. J. Neurosci. (2003) [Pubmed]
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