High impact information on ceh-43

• The Caenorhabditis elegans distal-less ortholog ceh-43 is required for development of the anterior hypodermis [1].
• These phenotypes suggest a role for ceh-43 in development of adhesive properties in the head hypodermis that connects the epithelia of the skin and the digestive tract [1].
• Working with the Caenorhabditis elegans homeobox gene ceh-43, the orthologue of fly Distal-less (Dll), we observed sequence similarity to the C. elegans gene fkh-1 [2].

Anatomical context of ceh-43

• GFP expression under the control of the ceh-43 promoter looks similar, although strong expression is primarily confined to the head hypodermis and to neuronal support cells. ceh-43(RNAi) results in 100% lethality at embryonic or early larval stages [1].

References