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Gene Review

ceh-39  -  Protein CEH-39

Caenorhabditis elegans

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Disease relevance of homeobox

  • Further studies should determine the specific role of these four homeobox genes in the development and progression of human breast cancer and potentially determine if they might be good targets for gene therapy [1].

High impact information on homeobox

  • We elucidate the tissue-specific expression of several miRNAs during embryogenesis, including two encoded by genes embedded in homeobox (Hox) clusters, miR-10a and miR-196a [2].
  • Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39 [3].
  • mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans [4].
  • Developmental biology. Homing in on the homeobox [5].
  • Recent progress ranges from the analysis of the control of promoter expression by homeobox genes to detailed analysis of the sites of homophilic and heterophilic interactions via mutagenesis strategies [6].

Biological context of homeobox


Anatomical context of homeobox


Other interactions of homeobox


Analytical, diagnostic and therapeutic context of homeobox


  1. Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype. Castronovo, V., Kusaka, M., Chariot, A., Gielen, J., Sobel, M. Biochem. Pharmacol. (1994) [Pubmed]
  2. MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Mansfield, J.H., Harfe, B.D., Nissen, R., Obenauer, J., Srineel, J., Chaudhuri, A., Farzan-Kashani, R., Zuker, M., Pasquinelli, A.E., Ruvkun, G., Sharp, P.A., Tabin, C.J., McManus, M.T. Nat. Genet. (2004) [Pubmed]
  3. Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39. Clark, S.G., Chisholm, A.D., Horvitz, H.R. Cell (1993) [Pubmed]
  4. mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans. Way, J.C., Chalfie, M. Cell (1988) [Pubmed]
  5. Developmental biology. Homing in on the homeobox. Riddihough, G. Nature (1992) [Pubmed]
  6. Factors regulating the expression and function of calcium-independent cell adhesion molecules. Walsh, F.S., Doherty, P. Curr. Opin. Cell Biol. (1993) [Pubmed]
  7. Hox gene evolution in nematodes: novelty conserved. Aboobaker, A., Blaxter, M. Curr. Opin. Genet. Dev. (2003) [Pubmed]
  8. Cloning and analysis of three new homeobox genes from the nematode Caenorhabditis elegans. Schaller, D., Wittmann, C., Spicher, A., Müller, F., Tobler, H. Nucleic Acids Res. (1990) [Pubmed]
  9. A novel class of plant proteins containing a homeodomain with a closely linked leucine zipper motif. Ruberti, I., Sessa, G., Lucchetti, S., Morelli, G. EMBO J. (1991) [Pubmed]
  10. Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Hobert, O., Mori, I., Yamashita, Y., Honda, H., Ohshima, Y., Liu, Y., Ruvkun, G. Neuron (1997) [Pubmed]
  11. The myogenic potency of HLH-1 reveals wide-spread developmental plasticity in early C. elegans embryos. Fukushige, T., Krause, M. Development (2005) [Pubmed]
  12. The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. Hobert, O., Tessmar, K., Ruvkun, G. Development (1999) [Pubmed]
  13. The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Aspöck, G., Ruvkun, G., Bürglin, T.R. Development (2003) [Pubmed]
  14. Misexpression of acetylcholinesterases in the C. elegans pha-2 mutant accompanies ultrastructural defects in pharyngeal muscle cells. Mörck, C., Axäng, C., Goksör, M., Pilon, M. Dev. Biol. (2006) [Pubmed]
  15. Identification of a homeobox-containing gene located between lin-45 and unc-24 on chromosome IV in the nematode Caenorhabditis elegans. Naito, M., Kohara, Y., Kurosawa, Y. Nucleic Acids Res. (1992) [Pubmed]
  16. The LIM homeobox gene ceh-14 confers thermosensory function to the AFD neurons in Caenorhabditis elegans. Cassata, G., Kagoshima, H., Andachi, Y., Kohara, Y., Dürrenberger, M.B., Hall, D.H., Bürglin, T.R. Neuron (2000) [Pubmed]
  17. Identification of planarian homeobox sequences indicates the antiquity of most Hox/homeotic gene subclasses. Balavoine, G., Telford, M.J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  18. Conservation of Hox/ParaHox-related genes in the early development of a cnidarian. Yanze, N., Spring, J., Schmidli, C., Schmid, V. Dev. Biol. (2001) [Pubmed]
  19. Vsx-1 and Vsx-2: two Chx10-like homeobox genes expressed in overlapping domains in the adult goldfish retina. Levine, E.M., Passini, M., Hitchcock, P.F., Glasgow, E., Schechter, N. J. Comp. Neurol. (1997) [Pubmed]
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