High impact information on nex-1

• Examination of transgenic offspring revealed specific nex-1 promoter activity in the pharynx, the hypodermal cells, the vulva, and the spermathecal valve, locations in which the annexin may function in collagen secretion/deposition and membrane-membrane interactions [1].
• Chromaffin granule aggregation was similarly promoted by the nex-1 protein at 630 microM calcium [1].
• A sensitive anti-nex-1 antibody labelled with rhodamine was injected into body cavities of the nematode but did not detect extracellular nex-1 protein [1].

Analytical, diagnostic and therapeutic context of nex-1

• The nex-1 annexin was localized in the nematode by immunofluorescence and by electron microscopy using immunogold labeling [2].
• Sequences including the nex-1 promoter were fused to the gene for green fluorescent protein and this construct was introduced into nematodes by microinjection [1].

References