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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

sma-2  -  Protein SMA-2

Caenorhabditis elegans

 
 
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High impact information on sma-2

  • We show that sma-2 functions in the same cells as daf-4, consistent with a role in transducing signals from the receptor [1].
  • Three Smad genes, sma-2, sma-3 and sma-4, are all required for signal transduction, suggesting that the functional complex could be a heterotrimer [2].
  • To understand the mechanisms of body size control in C. elegans, we analysed sma-2, sma-4 and sma-6 small mutants in the DBL-1 pathway [3].
 

Biological context of sma-2

  • We have identified a new member of the TGF-beta superfamily, CET-1, from Caenorhabditis elegans, which is expressed in the ventral nerve cord and other neurons. cet-1 null mutants have shortened bodies and male tail abnormal phenotype resembling sma mutants, suggesting cet-1, sma-2, sma-3 and sma-4 share a common pathway [4].

References

  1. Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components. Savage, C., Das, P., Finelli, A.L., Townsend, S.R., Sun, C.Y., Baird, S.E., Padgett, R.W. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. C-terminal mutants of C. elegans Smads reveal tissue-specific requirements for protein activation by TGF-beta signaling. Wang, J., Mohler, W.A., Savage-Dunn, C. Development (2005) [Pubmed]
  3. Mechanisms for the control of body size by a G-kinase and a downstream TGFbeta signal pathway in Caenorhabditis elegans. Nagamatsu, Y., Ohshima, Y. Genes Cells (2004) [Pubmed]
  4. Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family. Morita, K., Chow, K.L., Ueno, N. Development (1999) [Pubmed]
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