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Gene Review:

daf-4 - Protein DAF-4

Caenorhabditis elegans

Gunther, C.V. et al., Hawdon, J.M. et al., Inoue, T. et al., Golden, J.W. et al., Gunther, C.V. et al., et al.

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High impact information on daf-4

We show that sma-2 functions in the same cells as daf-4, consistent with a role in transducing signals from the receptor [1].
One daf-4 and one daf-7 allele are suppressed by the amber nonsense suppressor, sup-7(st5) [2].
Transgenic expression of a recombinant daf-4 transgene that encodes only the 2.0 kb mRNA enhances the Daf-c phenotype of a daf-4 hypomorph, whereas the same transgene with a nonsense mutation does not [3].
Alternative polyadenylation results in a truncated daf-4 BMP receptor that antagonizes DAF-7-mediated development in Caenorhabditis elegans [3].
We also studied the cellular targets of DAF-7 signaling by studying the sites of action of daf-14 and daf-4, the putative receptor for DAF-7. daf-14::gfp is expressed in multiple tissues that are remodeled during dauer formation [4].

Biological context of daf-4

All known mutations in daf-4 (eight alleles) and daf-7 (five alleles) produce a ts dauer-constitutive phenotype [2].

Other interactions of daf-4

In strains which are chronically starved as a result of mutations which compromise feeding behaviour (unc-52) or nutrient uptake into the intestinal cells (daf-4), cathepsin D levels are decreased to about 15% of the level in fully fed wild-type animals [5].

Analytical, diagnostic and therapeutic context of daf-4

The daf-4 gene encodes a type II bone morphogenetic protein receptor in Caenorhabditis elegans that regulates dauer larva formation, body size and male tail patterning [6].

References

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components. Savage, C., Das, P., Finelli, A.L., Townsend, S.R., Sun, C.Y., Baird, S.E., Padgett, R.W. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. Golden, J.W., Riddle, D.L. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
Alternative polyadenylation results in a truncated daf-4 BMP receptor that antagonizes DAF-7-mediated development in Caenorhabditis elegans. Gunther, C.V., Riddle, D.L. J. Biol. Chem. (2004) [Pubmed]
Targets of TGF-beta signaling in Caenorhabditis elegans dauer formation. Inoue, T., Thomas, J.H. Dev. Biol. (2000) [Pubmed]
Regulation of proteinase levels in the nematode Caenorhabditis elegans. Preferential depression by acute or chronic starvation. Hawdon, J.M., Emmons, S.W., Jacobson, L.A. Biochem. J. (1989) [Pubmed]
A Caenorhabditis elegans type I TGF beta receptor can function in the absence of type II kinase to promote larval development. Gunther, C.V., Georgi, L.L., Riddle, D.L. Development (2000) [Pubmed]

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