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Gene Review:

lin-9 - Protein LIN-9

Caenorhabditis elegans

Beitel, G.J. et al., Gagrica, S. et al., Boxem, M. et al.

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Disease relevance of lin-9

Genetic studies in Caenorhabditis elegans identified lin-9 to function together with the retinoblastoma homologue lin-35 in vulva differentiation [1].

High impact information on lin-9

In addition, we identified a negative G(1) regulatory function for lin-9 ALY, as well as lin-15B and lin-36, which encode novel proteins [2].
The Caenorhabditis elegans gene lin-9 functions in an Rb-related pathway that acts antagonistically to a receptor tyrosine kinase/Ras signal transduction pathway controlling vulval induction [3].

References

Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein. Gagrica, S., Hauser, S., Kolfschoten, I., Osterloh, L., Agami, R., Gaubatz, S. EMBO J. (2004) [Pubmed]
C. elegans class B synthetic multivulva genes act in G(1) regulation. Boxem, M., van den Heuvel, S. Curr. Biol. (2002) [Pubmed]
The C. elegans gene lin-9,which acts in an Rb-related pathway, is required for gonadal sheath cell development and encodes a novel protein. Beitel, G.J., Lambie, E.J., Horvitz, H.R. Gene (2000) [Pubmed]

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lin9	Xenopus (Silurana) tropicalis

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