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Gene Review

tlk-1  -  Protein TLK-1

Caenorhabditis elegans

 
 
 
 
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High impact information on tlk-1

  • The C. elegans Tousled-like kinase contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase [1].
  • Here, we used RNA mediated interference (RNAi) to determine the function of the C. elegans Tousled kinase (TLK-1) during embryonic development [2].
  • RESULTS: TLK-1-deficient embryos arrested with a phenotype reminiscent of embryos that are broadly defective in transcription, and the expression of several reporter genes was dramatically reduced in tlk-1(RNAi) embryos [2].

References

  1. The C. elegans Tousled-like kinase contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase. Han, Z., Riefler, G.M., Saam, J.R., Mango, S.E., Schumacher, J.M. Curr. Biol. (2005) [Pubmed]
  2. The C. elegans Tousled-like kinase (TLK-1) has an essential role in transcription. Han, Z., Saam, J.R., Adams, H.P., Mango, S.E., Schumacher, J.M. Curr. Biol. (2003) [Pubmed]
 
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