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Gene Review

TLK2  -  tousled-like kinase 2

Homo sapiens

Synonyms: HsHPK, MGC44450, PKU-ALPHA, PKU-alpha, Serine/threonine-protein kinase tousled-like 2, ...
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Disease relevance of TLK2


High impact information on TLK2


Biological context of TLK2


Associations of TLK2 with chemical compounds

  • The deduced aa sequences of PKU-alpha and PKU-beta contained typical serine/threonine PK domains at the C-terminal region and were 86% identical to each other, indicating that they belong to the same PK family [2].


  1. Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type 1 patients. Van Roy, N., Vandesompele, J., Berx, G., Staes, K., Van Gele, M., De Smet, E., De Paepe, A., Laureys, G., van der Drift, P., Versteeg, R., Van Roy, F., Speleman, F. Genes Chromosomes Cancer (2002) [Pubmed]
  2. cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal. Yamakawa, A., Kameoka, Y., Hashimoto, K., Yoshitake, Y., Nishikawa, K., Tanihara, K., Date, T. Gene (1997) [Pubmed]
  3. Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. Silljé, H.H., Nigg, E.A. Curr. Biol. (2001) [Pubmed]
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