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Gene Review:

rib-2 - Protein RIB-2

Caenorhabditis elegans

Morio, H. et al., Kim, B.T. et al., Kitagawa, H. et al.

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High impact information on rib-2

These results suggest the essential roles of DEXT3, its human ortholog EXTL3, and the C. elegans ortholog rib-2 in the biosynthesis of heparan sulfate and heparin, if present, in the respective organisms [1].
Only two homologous genes, rib-1 and rib-2, of the mammalian EXT genes were identified in the Caenorhabditis elegans genome [2].
These results indicate that rib-2 is essential for embryonic development and heparan sulfate biosynthesis in C. elegans [3].
Inactivation of rib-2 alleles induced developmental abnormalities in F2 and F3 homozygous worms, while F1 heterozygotes showed a normal morphology [3].

Associations of rib-2 with chemical compounds

The analysis using fluorometric post-column high-performance liquid chromatography also uncovered reduced production of heparan sulfate in the rib-2 mutant [3].

References

Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation. Kim, B.T., Kitagawa, H., Tamura Ji, J., Kusche-Gullberg, M., Lindahl, U., Sugahara, K. J. Biol. Chem. (2002) [Pubmed]
rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate. Kitagawa, H., Egusa, N., Tamura, J.I., Kusche-Gullberg, M., Lindahl, U., Sugahara, K. J. Biol. Chem. (2001) [Pubmed]
EXT gene family member rib-2 is essential for embryonic development and heparan sulfate biosynthesis in Caenorhabditis elegans. Morio, H., Honda, Y., Toyoda, H., Nakajima, M., Kurosawa, H., Shirasawa, T. Biochem. Biophys. Res. Commun. (2003) [Pubmed]

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