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Gene Review:

unc-119 - Protein UNC-119

Caenorhabditis elegans

Maduro, M. et al., Materi, W. et al., Knobel, K.M. et al., Swanson, D.A. et al.

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High impact information on unc-119

In unc-119 mutants, motor neuron commissures are excessively branched in adults [1].
Mammalian orthologs of C. elegans unc-119 highly expressed in photoreceptors [2].
Expression of an unc-119/lacZ fusion in transgenic animals is seen in many neurons, suggesting that the unc-119 mutant phenotype is due to a defect in the nervous system [3].
Worms mutant for unc-119 exhibit nervous system structural defects, including supernumerary axon branches, defasciculated nerve fibers, and choice point errors [4].

References

UNC-119 suppresses axon branching in C. elegans. Knobel, K.M., Davis, W.S., Jorgensen, E.M., Bastiani, M.J. Development (2001) [Pubmed]
Mammalian orthologs of C. elegans unc-119 highly expressed in photoreceptors. Swanson, D.A., Chang, J.T., Campochiaro, P.A., Zack, D.J., Valle, D. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system. Maduro, M., Pilgrim, D. Genetics (1995) [Pubmed]
Novel Caenorhabditis elegans unc-119 axon outgrowth defects correlate with behavioral phenotypes that are partially rescued by nonneural unc-119. Materi, W., Pilgrim, D. Genesis (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

UNC119B	Bos taurus
UNC119B	Canis lupus familiaris
unc119.1	Danio rerio
UNC119B	Gallus gallus
UNC119B	Homo sapiens
UNC119B	Macaca mulatta
Unc119b	Mus musculus
UNC119B	Pan troglodytes
Unc119b	Rattus norvegicus
unc119b	Xenopus (Silurana) tropicalis

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