Gene Review:
gab-1 - Protein GAB-1
Caenorhabditis elegans
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High impact information on gab-1
- To explore the functional properties of the two alleles, a full-length cDNA encoding the beta subunit, a key functional component of the GABA receptor, was isolated from Caenorhabditis elegans (gab-1, corresponding to the GenBank locus ZC482.1) and coexpressed in Xenopus oocytes with the HG1 alleles [1].
Anatomical context of gab-1
- When gab-1 was coexpressed with either the HG1A allele or the HG1E allele in Xenopus oocytes, gamma-aminobutyric acid (GABA)-responsive channels with different sensitivity to the agonist were formed [1].
References
- Study of the nematode putative GABA type-A receptor subunits: evidence for modulation by ivermectin. Feng, X.P., Hayashi, J., Beech, R.N., Prichard, R.K. J. Neurochem. (2002) [Pubmed]
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