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Gene Review:

unc-33 - Protein UNC-33

Caenorhabditis elegans

Matsuo, T. et al., Kamata, T. et al., Byk, T. et al., Quach, T.T. et al., Goshima, Y. et al., et al.

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Disease relevance of unc-33

Mutations in the C. elegans unc-33 gene lead to worms with abnormal movements [1].
It contains 15 exons, including an exon defined by an anaplastic oligodendroglioma expressed sequence tag, and spans at least 61.7 kilobases. hUlip lacks sequences corresponding to the first six exons found in unc-33. unc-33 exons correspond to homologous hUlip exons as follows: VII to 1 and 2, VIII to 3-9, IX to 10-12, and X to 13 and 14 [1].

High impact information on unc-33

The amino acid sequence of the mouse protein deduced from its cloned cDNA reveals similarities with that of the neuritic outgrowth- and guidance-related product of the unc-33 gene in Caenorhabditis elegans [2].
The unc-33 mutation specifically affects neuronal microtubules [3].

Biological context of unc-33

The deduced amino acid sequence reveals that the gene encodes a protein of 572 amino acids and is highly homologous to Caenorhabditis elegans unc-33, which controls the guidance and outgrowth of neuronal axons [4].
Mutations in unc-33 affect neural microtubules, the basic cytoskeletal elements for axoplasmic transport [5].

Analytical, diagnostic and therapeutic context of unc-33

Sequence analysis indicates that 7G1 is homologous to the Caenorhabditis elegans gene unc-33 [6].
Molecular cloning of a new unc-33-like cDNA from rat brain and its relation to paraneoplastic neurological syndromes [7].

References

Structure and promoter analysis of the human unc-33-like phosphoprotein gene. E-box required for maximal expression in neuroblastoma and myoblasts. Matsuo, T., Stauffer, J.K., Walker, R.L., Meltzer, P., Thiele, C.J. J. Biol. Chem. (2000) [Pubmed]
Identification and molecular characterization of Unc-33-like phosphoprotein (Ulip), a putative mammalian homolog of the axonal guidance-associated unc-33 gene product. Byk, T., Dobransky, T., Cifuentes-Diaz, C., Sobel, A. J. Neurosci. (1996) [Pubmed]
Axonal guidance mutants of Caenorhabditis elegans identified by filling sensory neurons with fluorescein dyes. Hedgecock, E.M., Culotti, J.G., Thomson, J.N., Perkins, L.A. Dev. Biol. (1985) [Pubmed]
Isolation and characterization of a bovine neural specific protein (CRMP-2) cDNA homologous to unc-33, a C. elegans gene implicated in axonal outgrowth and guidance. Kamata, T., Subleski, M., Hara, Y., Yuhki, N., Kung, H., Copeland, N.G., Jenkins, N.A., Yoshimura, T., Modi, W., Copeland, T.D. Brain Res. Mol. Brain Res. (1998) [Pubmed]
A novel action of collapsin: collapsin-1 increases antero- and retrograde axoplasmic transport independently of growth cone collapse. Goshima, Y., Kawakami, T., Hori, H., Sugiyama, Y., Takasawa, S., Hashimoto, Y., Kagoshima-Maezono, M., Takenaka, T., Misu, Y., Strittmatter, S.M. J. Neurobiol. (1997) [Pubmed]
Identification and characterization of a retinoic acid-regulated human homologue of the unc-33-like phosphoprotein gene (hUlip) from neuroblastoma cells. Gaetano, C., Matsuo, T., Thiele, C.J. J. Biol. Chem. (1997) [Pubmed]
Molecular cloning of a new unc-33-like cDNA from rat brain and its relation to paraneoplastic neurological syndromes. Quach, T.T., Rong, Y., Belin, M.F., Duchemin, A.M., Akaoka, H., Ding, S., Baudry, M., Kolattukudy, P.E., Honnorat, J. Brain Res. Mol. Brain Res. (1997) [Pubmed]

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