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Gene Review:

ubc-1 - Protein UBC-1

Caenorhabditis elegans

Furukawa, M. et al., Crowe, E. et al., Leggett, D.S. et al.

Crowe, Candido,

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High impact information on ubc-1

Cullin family proteins bind with the RING-finger protein Roc1 to recruit the ubiquitin-conjugating enzyme (E2) to the ubiquitin ligase complex (E3) [1].
By contrast, RNA interference against ubc-1 gave no obvious phenotype, suggesting that ubc-1 is nonessential or is functionally redundant [2].
Both cis and trans splicing are involved in the maturation of the ubc-1 transcript [3].

References

Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Furukawa, M., He, Y.J., Borchers, C., Xiong, Y. Nat. Cell Biol. (2003) [Pubmed]
Characterization of C. elegans RING finger protein 1, a binding partner of ubiquitin-conjugating enzyme 1. Crowe, E., Candido, E.P. Dev. Biol. (2004) [Pubmed]
Caenorhabditis elegans UBC-1, a ubiquitin-conjugating enzyme homologous to yeast RAD6/UBC2, contains a novel carboxy-terminal extension that is conserved in nematodes. Leggett, D.S., Jones, D., Candido, E.P. DNA Cell Biol. (1995) [Pubmed]

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UBC2	Arabidopsis thaliana
UBC1	Arabidopsis thaliana
UBE2A	Canis lupus familiaris
ube2a	Danio rerio
UBE2A	Gallus gallus
UBE2A	Homo sapiens
UBE2A	Macaca mulatta
Ube2a	Mus musculus
Os05g0182500	Oryza sativa Japonica Group
Os03g0791800	Oryza sativa Japonica Group
Os07g0166800	Oryza sativa Japonica Group
UBE2A	Pan troglodytes
Ube2a	Rattus norvegicus
ube2a	Xenopus (Silurana) tropicalis

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