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Gene Review

UBE2A  -  ubiquitin-conjugating enzyme E2A

Homo sapiens

Synonyms: HHR6A, HR6A, MRXS30, MRXSN, RAD6 homolog A, ...
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Disease relevance of UBE2A


High impact information on UBE2A


Biological context of UBE2A


Other interactions of UBE2A

  • Two closely related human homologs of yeast Rad6 have been identified as HHR6A and HHR6B [8].
  • Thus, through interaction and complex formation with HHR6A and HHR6B, RAD18 protein may play an important role in lesion bypass mechanisms in humans [8].


  1. UBE2A, which encodes a ubiquitin-conjugating enzyme, is mutated in a novel X-linked mental retardation syndrome. Nascimento, R.M., Otto, P.A., de Brouwer, A.P., Vianna-Morgante, A.M. Am. J. Hum. Genet. (2006) [Pubmed]
  2. Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation. Sarcevic, B., Mawson, A., Baker, R.T., Sutherland, R.L. EMBO J. (2002) [Pubmed]
  3. Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. Koken, M.H., Reynolds, P., Jaspers-Dekker, I., Prakash, L., Prakash, S., Bootsma, D., Hoeijmakers, J.H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  4. RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Kim, J., Guermah, M., McGinty, R.K., Lee, J.S., Tang, Z., Milne, T.A., Shilatifard, A., Muir, T.W., Roeder, R.G. Cell. (2009) [Pubmed]
  5. Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination. Watanabe, K., Tateishi, S., Kawasuji, M., Tsurimoto, T., Inoue, H., Yamaizumi, M. EMBO. J. (2004) [Pubmed]
  6. Molecular cloning and characterization of cDNA encoding a ubiquitin-conjugating enzyme from Clonorchis sinensis. Song, L., Chen, S., Yu, X., Wu, Z., Xu, J., Yang, G., Zheng, N., Hu, X., Guo, L., Dai, J., Xu, J., Ji, C., Gu, S., Ying, K. Parasitol. Res. (2004) [Pubmed]
  7. Specific aspects of the ubiquitin system in spermatogenesis. Baarends, W.M., van der Laan, R., Grootegoed, J.A. J. Endocrinol. Invest. (2000) [Pubmed]
  8. The human RAD18 gene product interacts with HHR6A and HHR6B. Xin, H., Lin, W., Sumanasekera, W., Zhang, Y., Wu, X., Wang, Z. Nucleic Acids Res. (2000) [Pubmed]
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