Disease relevance of Ube2a

• Just like mHR6B knockout mouse embryonic fibroblasts, mHR6A-deficient cells appear to have normal DNA damage resistance properties, but mHR6A knockout male and female mice display a small decrease in body weight [1].

High impact information on Ube2a

• These observations support redundant but dose-dependent roles for HR6A and HR6B in somatic cell types and germ line cells in mammals [1].
• The absence of mHR6A in oocytes prevents development beyond the embryonic two-cell stage but does not result in an aberrant methylation pattern of histone H3 at this early stage of mouse embryonic development [1].
• Here, we describe the phenotype of cells and mice deficient for the mHR6A gene [1].
• However, mHR6A knockout females fail to produce offspring despite a normal ovarian histology and ovulation [1].
• The chromosomal localizations of two closely related human DNA repair genes, HHR6A and HHR6B, were determined by in situ hybridization with biotinylated probes [2].

Biological context of Ube2a

• Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31 [2].

References