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Gene Review

cul-1  -  Protein CUL-1

Caenorhabditis elegans

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Disease relevance of cul-1


High impact information on cul-1


Anatomical context of cul-1

  • We also found an increase in cul-1 transcription in cultured cells treated with a lethal dose of gamma-irradiation [6].
  • We propose that segregation of the germ plasm involves both stabilization of germline proteins in the germ line and cullin-dependent degradation in the soma [7].

Other interactions of cul-1

  • We propose that Nedd8-modified cullin, as part of an E3 ubiquitin ligase complex, targets katanin for degradation during the transition from meiosis to mitosis [8].
  • Many F-box proteins are target recognition subunits of SCF (Skp, Cullin, F-box) ubiquitin-ligase complexes. fsn-1 functions in the same pathway as rpm-1, a gene encoding a large protein with RING finger domains [9].


  1. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Kipreos, E.T., Lander, L.E., Wing, J.P., He, W.W., Hedgecock, E.M. Cell (1996) [Pubmed]
  2. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Furukawa, M., He, Y.J., Borchers, C., Xiong, Y. Nat. Cell Biol. (2003) [Pubmed]
  3. Zyg-11 and cul-2 regulate progression through meiosis II and polarity establishment in C. elegans. Sonneville, R., Gönczy, P. Development (2004) [Pubmed]
  4. Mutations in cye-1, a Caenorhabditis elegans cyclin E homolog, reveal coordination between cell-cycle control and vulval development. Fay, D.S., Han, M. Development (2000) [Pubmed]
  5. Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans. Pintard, L., Kurz, T., Glaser, S., Willis, J.H., Peter, M., Bowerman, B. Curr. Biol. (2003) [Pubmed]
  6. Temporal and spatial expression of the cell-cycle regulator cul-1 in Drosophila and its stimulation by radiation-induced apoptosis. Filippov, V., Filippova, M., Sehnal, F., Gill, S.S. J. Exp. Biol. (2000) [Pubmed]
  7. Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation. DeRenzo, C., Reese, K.J., Seydoux, G. Nature (2003) [Pubmed]
  8. Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway. Kurz, T., Pintard, L., Willis, J.H., Hamill, D.R., Gönczy, P., Peter, M., Bowerman, B. Science (2002) [Pubmed]
  9. An SCF-like ubiquitin ligase complex that controls presynaptic differentiation. Liao, E.H., Hung, W., Abrams, B., Zhen, M. Nature (2004) [Pubmed]
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