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Gene Review:

pes-1 - Protein PES-1

Caenorhabditis elegans

Molin, L. et al., Hope, I.A., Molin, L. et al.

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High impact information on pes-1

Conservation of the fkh-2/pes-1 genetic redundancy between C. elegans and the related species C. briggsae was demonstrated [1].
Despite these observations suggesting pes-1 to have an important regulatory role in embryogenesis, inactivation of pes-1 caused no apparent phenotype [1].
The beta-galactosidase expression pattern, directed by the pes-1/lacZ fusion through which this gene was cloned, has been determined precisely in terms of the embryonic cell lineage and has three components [2].
Complexity of developmental control: analysis of embryonic cell lineage specification in Caenorhabditis elegans using pes-1 as an early marker [3].

Biological context of pes-1

Promoter trapping has identified a gene, pes-1, which is expressed during C. elegans embryogenesis [2].
Whereas a weak, transitory effect was observed upon disruption of just T14G12.4 (renamed fkh-2) gene function, simultaneous disruption of the activity of both fkh-2 and pes-1 resulted in a penetrant lethal phenotype [1].

References

Evolutionary conservation of redundancy between a diverged pair of forkhead transcription factor homologues. Molin, L., Mounsey, A., Aslam, S., Bauer, P., Young, J., James, M., Sharma-Oates, A., Hope, I.A. Development (2000) [Pubmed]
PES-1 is expressed during early embryogenesis in Caenorhabditis elegans and has homology to the fork head family of transcription factors. Hope, I.A. Development (1994) [Pubmed]
Complexity of developmental control: analysis of embryonic cell lineage specification in Caenorhabditis elegans using pes-1 as an early marker. Molin, L., Schnabel, H., Kaletta, T., Feichtinger, R., Hope, I.A., Schnabel, R. Genetics (1999) [Pubmed]

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