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Gene Review

drp-1  -  Protein DRP-1

Caenorhabditis elegans

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Disease relevance of drp-1

  • Mutant DRP-1 causes the mitochondrial matrix to retract into large blebs that are both surrounded and connected by tubules of outer membrane [1].

High impact information on drp-1

  • Overexpressed wild-type DRP-1 causes mitochondria to become excessively fragmented, consistent with an active role in mitochondrial scission [1].
  • Furthermore, DRP-1/dynamin-related protein, a key component of the mitochondrial fission machinery, is required and sufficient to induce mitochondrial fragmentation and programmed cell death during C. elegans development [2].


  1. C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Labrousse, A.M., Zappaterra, M.D., Rube, D.A., van der Bliek, A.M. Mol. Cell (1999) [Pubmed]
  2. DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans. Jagasia, R., Grote, P., Westermann, B., Conradt, B. Nature (2005) [Pubmed]
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