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Gene Review:

Dnm1l - dynamin 1-like

Mus musculus

Synonyms: 6330417M19Rik, AI450666, Dlp1, Dnmlp1, Drp1, ...

De Vos, K.J. et al., Frezza, C. et al., Cipolat, S. et al., Misaka, T. et al., Yoshinaga, K. et al., et al.

De Vos, Allan, Grierson, Sheetz, Misaka, Murate, Fujimoto, Kubo,

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Disease relevance of Dnm1l

Here we provide evidence that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy, protects from apoptosis by preventing cytochrome c release independently from mitochondrial fusion [1].
It is unclear whether OPA1, a dynamin-related protein of the inner membrane mutated in autosomal dominant optic atrophy, participates in fusion or fission [2].

High impact information on Dnm1l

Furthermore, our results suggest that the actin cytoskeleton is involved in mitochondrial fission by facilitating mitochondrial recruitment of DRP1 [3].
Mitochondrial fission depended on dynamin-related protein 1 (DRP1) and F-actin: Disruption of F-actin attenuated fission and recruitment of DRP1 to mitochondria [3].
Overall, receptor down-regulation associated with chronic etorphine treatment may accelerate dynamin-related activity [4].
A dynamin-related protein (DRP) associated with mitochondrial outer membrane fission is known to be involved in the regulation of apoptosis [5].
The dynamin-related mouse mitochondrial GTPase OPA1 alters the structure of the mitochondrial inner membrane when exogenously introduced into COS-7 cells [6].

References

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Frezza, C., Cipolat, S., Martins de Brito, O., Micaroni, M., Beznoussenko, G.V., Rudka, T., Bartoli, D., Polishuck, R.S., Danial, N.N., De Strooper, B., Scorrano, L. Cell (2006) [Pubmed]
OPA1 requires mitofusin 1 to promote mitochondrial fusion. Cipolat, S., Martins de Brito, O., Dal Zilio, B., Scorrano, L. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
Mitochondrial function and actin regulate dynamin-related protein 1-dependent mitochondrial fission. De Vos, K.J., Allan, V.J., Grierson, A.J., Sheetz, M.P. Curr. Biol. (2005) [Pubmed]
Opioid agonists differentially regulate mu-opioid receptors and trafficking proteins in vivo. Patel, M.B., Patel, C.N., Rajashekara, V., Yoburn, B.C. Mol. Pharmacol. (2002) [Pubmed]
The mitochondrial fission regulator DRP3B does not regulate cell death in plants. Yoshinaga, K., Fujimoto, M., Arimura, S., Tsutsumi, N., Uchimiya, H., Kawai-Yamada, M. Ann. Bot. (2006) [Pubmed]
The dynamin-related mouse mitochondrial GTPase OPA1 alters the structure of the mitochondrial inner membrane when exogenously introduced into COS-7 cells. Misaka, T., Murate, M., Fujimoto, K., Kubo, Y. Neurosci. Res. (2006) [Pubmed]

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AGOS_AAL174C	Ashbya gossypii ATCC 10895
DNM1L	Bos taurus
drp-1	Caenorhabditis elegans
DNM1L	Canis lupus familiaris
dnm1l	Danio rerio
Drp1	Drosophila melanogaster
DNM1L	Gallus gallus
DNM1L	Homo sapiens
KLLA0F12892g	Kluyveromyces lactis NRRL Y-1140
DNM1L	Macaca mulatta
MGG_06361	Magnaporthe oryzae 70-15
NCU09808	Neurospora crassa OR74A
Os04g0381000	Oryza sativa Japonica Group
DNM1L	Pan troglodytes
Dnm1l	Rattus norvegicus
DNM1	Saccharomyces cerevisiae S288c
dnm1	Schizosaccharomyces pombe 972h-
dnm1l	Xenopus (Silurana) tropicalis

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