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Gene Review

unc-44  -  Protein UNC-44

Caenorhabditis elegans

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Disease relevance of unc-44


High impact information on unc-44

  • An ankyrin-related gene (unc-44) is necessary for proper axonal guidance in Caenorhabditis elegans [1].
  • Genetic screens in animals that express the green fluorescent protein in a subset of sensory neurons identified eight new sax genes that affect the morphology of nerve ring axons. sax-3/robo mutations disrupt axon guidance in the nerve ring, while sax-5, sax-9 and unc-44 disrupt both axon guidance and axon extension [2].


  1. An ankyrin-related gene (unc-44) is necessary for proper axonal guidance in Caenorhabditis elegans. Otsuka, A.J., Franco, R., Yang, B., Shim, K.H., Tang, L.Z., Zhang, Y.Y., Boontrakulpoontawee, P., Jeyaprakash, A., Hedgecock, E., Wheaton, V.I. J. Cell Biol. (1995) [Pubmed]
  2. Genes required for axon pathfinding and extension in the C. elegans nerve ring. Zallen, J.A., Kirch, S.A., Bargmann, C.I. Development (1999) [Pubmed]
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