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MeSH Review


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Disease relevance of Fasciculation


Psychiatry related information on Fasciculation


High impact information on Fasciculation


Chemical compound and disease context of Fasciculation

  • We report here the complete cDNA sequence of F11 130 kd polypeptide, a chick neural cell surface-associated glycoprotein implicated in neurite fasciculation and elongation [13].
  • Neuronal migrations and axon fasciculation are disrupted in ina-1 integrin mutants [14].
  • The protein designated FEZ1 (fasciculation and elongation protein zeta-1) consisting of 393 amino acid residues shows a high Asp/Glu content and contains several regions predicted to form amphipathic helices [15].
  • When laminin was combined with polylysine in the substratum, the degree of fasciculation and rate of elongation were similar to those seen on laminin alone, whereas the tendency for clockwise outgrowth was even more pronounced than that observed with polylysine alone [16].
  • These edrophonium actions include the induction of a stimulus-dependent afterdischarge and the initiation of fasciculations [17].

Biological context of Fasciculation


Anatomical context of Fasciculation


Gene context of Fasciculation

  • Caenorhabditis elegans unc-44 mutations result in aberrant axon guidance and fasciculation with inappropriate partners [28].
  • Disruption of the spatial organization of the dri-expressing longitudinal glia accounts for the mild defects in axon fasciculation observed in the mutant embryos [29].
  • The development and differentiation of many neurons require the gene zag-1, which encodes a deltaEF1/ZFH-1 Zn-finger-homeodomain protein. zag-1 mutations cause misexpression of neuron-specific genes, block formation of stereotypic axon branches, perturb neuronal migrations, and induce various axon-guidance, fasciculation and branching errors [30].
  • The C. elegans hmr-1 gene can encode a neuronal classic cadherin involved in the regulation of axon fasciculation [31].
  • Here, we demonstrated the existence of DISC1 protein and identified fasciculation and elongation protein zeta-1 (FEZ1) as an interacting partner of DISC1 by a yeast two-hybrid study [32].

Analytical, diagnostic and therapeutic context of Fasciculation


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  2. Brachial plexopathy: recurrent cancer or radiation? Lederman, R.J., Wilbourn, A.J. Neurology (1984) [Pubmed]
  3. Primary amyloidosis with peripheral neuropathy and signs of motor neuron disease. Abarbanel, J.M., Frisher, S., Osimani, A. Neurology (1986) [Pubmed]
  4. Influence of ganglion age, nonneuronal cells and substratum on neurite outgrowth in culture. Roufa, D.G., Johnson, M.I., Bunge, M.B. Dev. Biol. (1983) [Pubmed]
  5. Hypertrophia musculorum vera in familial ataxia. O'Donnell, P.P., Leshner, R.T., Campbell, W.W. Arch. Neurol. (1986) [Pubmed]
  6. Effect of pregnenolone-16alpha-carbonitrile (PCN) on drug response in man. Szabo, S., Komblos, S., Ignjatovic, Z. J. Pharm. Pharmacol. (1975) [Pubmed]
  7. The pachygyria-polymicrogyria spectrum of cortical dysplasia in X-linked hydrocephalus. Graf, W.D., Born, D.E., Sarnat, H.B. European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie. (1998) [Pubmed]
  8. Disruption of the mouse L1 gene leads to malformations of the nervous system. Dahme, M., Bartsch, U., Martini, R., Anliker, B., Schachner, M., Mantei, N. Nat. Genet. (1997) [Pubmed]
  9. Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Henkemeyer, M., Orioli, D., Henderson, J.T., Saxton, T.M., Roder, J., Pawson, T., Klein, R. Cell (1996) [Pubmed]
  10. Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands. Holland, S.J., Gale, N.W., Mbamalu, G., Yancopoulos, G.D., Henkemeyer, M., Pawson, T. Nature (1996) [Pubmed]
  11. Developmental biology of a neural cell adhesion molecule. Rutishauser, U. Nature (1984) [Pubmed]
  12. Axon guidance and the patterning of neuronal projections in vertebrates. Dodd, J., Jessell, T.M. Science (1988) [Pubmed]
  13. Neural cell recognition molecule F11: homology with fibronectin type III and immunoglobulin type C domains. Brümmendorf, T., Wolff, J.M., Frank, R., Rathjen, F.G. Neuron (1989) [Pubmed]
  14. Neuronal migrations and axon fasciculation are disrupted in ina-1 integrin mutants. Baum, P.D., Garriga, G. Neuron (1997) [Pubmed]
  15. Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein. Kuroda, S., Nakagawa, N., Tokunaga, C., Tatematsu, K., Tanizawa, K. J. Cell Biol. (1999) [Pubmed]
  16. Laminin and optic nerve regeneration in the goldfish. Hopkins, J.M., Ford-Holevinski, T.S., McCoy, J.P., Agranoff, B.W. J. Neurosci. (1985) [Pubmed]
  17. Glucocorticoid effects on the edrophonium responsiveness of normal and degenerating mammalian motor nerve terminals. Hall, E.D., Riker, W.F., Baker, T. Ann. Neurol. (1977) [Pubmed]
  18. Intracellular signaling is changed after clustering of the neural cell adhesion molecules axonin-1 and NgCAM during neurite fasciculation. Kunz, S., Ziegler, U., Kunz, B., Sonderegger, P. J. Cell Biol. (1996) [Pubmed]
  19. Synaptogenesis in the giant-fibre system of Drosophila: interaction of the giant fibre and its major motorneuronal target. Jacobs, K., Todman, M.G., Allen, M.J., Davies, J.A., Bacon, J.P. Development (2000) [Pubmed]
  20. Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation. Suzuki, T., Okada, Y., Semba, S., Orba, Y., Yamanouchi, S., Endo, S., Tanaka, S., Fujita, T., Kuroda, S., Nagashima, K., Sawa, H. J. Biol. Chem. (2005) [Pubmed]
  21. "Self-taming" of succinylcholine-induced fasciculations and intraocular pressure. Verma, R.S. Anesthesiology (1979) [Pubmed]
  22. Pretreatment with d-tubocurarine, vecuronium, and pancuronium attenuates succinylcholine-induced increases in plasma norepinephrine concentrations in humans. Oshita, S., Denda, S., Fujiwara, Y., Takeshita, H., Kosaka, F. Anesth. Analg. (1991) [Pubmed]
  23. A homologue of the axonally secreted protein axonin-1 is an integral membrane protein of nerve fiber tracts involved in neurite fasciculation. Ruegg, M.A., Stoeckli, E.T., Lanz, R.B., Streit, P., Sonderegger, P. J. Cell Biol. (1989) [Pubmed]
  24. Effects of fasciculation on the outgrowth of neurites from spinal ganglia in culture. Rutishauser, U., Edelman, G.M. J. Cell Biol. (1980) [Pubmed]
  25. Pathfinding by neuronal growth cones in grasshopper embryos. II. Selective fasciculation onto specific axonal pathways. Raper, J.A., Bastiani, M., Goodman, C.S. J. Neurosci. (1983) [Pubmed]
  26. Analysis of high PSA N-CAM expression during mammalian spinal cord and peripheral nervous system development. Boisseau, S., Nedelec, J., Poirier, V., Rougon, G., Simonneau, M. Development (1991) [Pubmed]
  27. Identification of a novel neural cell adhesion molecule-related gene with a potential role in selective axonal projection. Alenius, M., Bohm, S. J. Biol. Chem. (1997) [Pubmed]
  28. An ankyrin-related gene (unc-44) is necessary for proper axonal guidance in Caenorhabditis elegans. Otsuka, A.J., Franco, R., Yang, B., Shim, K.H., Tang, L.Z., Zhang, Y.Y., Boontrakulpoontawee, P., Jeyaprakash, A., Hedgecock, E., Wheaton, V.I. J. Cell Biol. (1995) [Pubmed]
  29. The dead ringer/retained transcriptional regulatory gene is required for positioning of the longitudinal glia in the Drosophila embryonic CNS. Shandala, T., Takizawa, K., Saint, R. Development (2003) [Pubmed]
  30. C. elegans ZAG-1, a Zn-finger-homeodomain protein, regulates axonal development and neuronal differentiation. Clark, S.G., Chiu, C. Development (2003) [Pubmed]
  31. The C. elegans hmr-1 gene can encode a neuronal classic cadherin involved in the regulation of axon fasciculation. Broadbent, I.D., Pettitt, J. Curr. Biol. (2002) [Pubmed]
  32. Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Miyoshi, K., Honda, A., Baba, K., Taniguchi, M., Oono, K., Fujita, T., Kuroda, S., Katayama, T., Tohyama, M. Mol. Psychiatry (2003) [Pubmed]
  33. Contractures elicited by tetraethylammonium in avian muscle treated with methohexitone. Elliott, R.C. Br. J. Pharmacol. (1979) [Pubmed]
  34. Prevention of succinylcholine-induced fasciculation and myalgia: a meta-analysis of randomized trials. Schreiber, J.U., Lysakowski, C., Fuchs-Buder, T., Tramèr, M.R. Anesthesiology (2005) [Pubmed]
  35. Increase in intragastric pressure during suxamethonium-induced muscle fasciculations in children: inhibition by alfentanil. Lindgren, L., Saarnivaara, L. British journal of anaesthesia. (1988) [Pubmed]
  36. Attenuation of suxamethonium myalgias. Effect of midazolam and vecuronium. Mingus, M.L., Herlich, A., Eisenkraft, J.B. Anaesthesia. (1990) [Pubmed]
  37. Biochemical effects of succinylcholine chloride in mechanically ventilated horses anesthetized with halothane in oxygen. Benson, G.J., Hartsfield, S.M., Manning, J.P., Thurmon, J.C. Am. J. Vet. Res. (1980) [Pubmed]
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