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Gene Review:

mes-6 - Protein MES-6

Caenorhabditis elegans

Chesney, M.A. et al., Kelly, W.G. et al., Williams, C. et al., Holdeman, R. et al.

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High impact information on mes-6

We have analyzed the processing of an operon of this type by inserting the central part of mes-6/cks-1 into an SL2-type operon [1].
The proteins encoded by mes-2 and mes-6 have been shown to be related to the Polycomb Group of transcriptional repressors (Holdeman, R., Nehrt, S. and Strome, S. (1998). Development 125, 2457-2467; Korf, I., Fan, F. and Strome, S. (1998). Development 125, 2469-2478) [2].
The correct distribution of MES-2 requires the wild-type functions of mes-3 and mes-6 [3].

Biological context of mes-6

The gon-14 larval arrest is suppressed by loss of mes-2/E(Z), mes-6/ESC, or mes-4, which encodes a SET domain protein [4].

References

SL1 trans splicing and 3'-end formation in a novel class of Caenorhabditis elegans operon. Williams, C., Xu, L., Blumenthal, T. Mol. Cell. Biol. (1999) [Pubmed]
Chromatin silencing and the maintenance of a functional germline in Caenorhabditis elegans. Kelly, W.G., Fire, A. Development (1998) [Pubmed]
MES-2, a maternal protein essential for viability of the germline in Caenorhabditis elegans, is homologous to a Drosophila Polycomb group protein. Holdeman, R., Nehrt, S., Strome, S. Development (1998) [Pubmed]
gon-14 functions with class B and class C synthetic multivulva genes to control larval growth in Caenorhabditis elegans. Chesney, M.A., Kidd, A.R., Kimble, J. Genetics (2006) [Pubmed]

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