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Gene Review:

mes-3 - Protein MES-3

Caenorhabditis elegans

Paulsen, J.E. et al., Xu, L. et al., Xu, L. et al., Holdeman, R. et al.

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Disease relevance of mes-3

Depletion of a novel SET-domain protein enhances the sterility of mes-3 and mes-4 mutants of Caenorhabditis elegans [1].

High impact information on mes-3

The correct distribution of MES-2 requires the wild-type functions of mes-3 and mes-6 [2].
We tested seven genes predicted to encode regulators of chromatin organization for RNAi-induced enhancement of mes-3 sterility and identified one enhancer, called set-2 after the SET domain encoded by the gene [1].
The distribution of MES-3 in the adult germline is regulated by the translational repressor GLD-1: MES-3 is absent from the region of the germline where GLD-1 is known to be present, MES-3 is overexpressed in the germline of gld-1 mutants, and GLD-1 specifically binds the mes-3 3' untranslated region (3' UTR) [3].
The few germ cells that appear healthy in mes-3 worms do not differentiate into gametes, even after elimination of the signaling pathway that normally maintains the undifferentiated population of germ cells [4].
Both mes-3 and the downstream gene in the operon encode novel proteins [4].

Biological context of mes-3

Both the appearance of the dying germ cells and the results of genetic tests indicate that germ cells in mes-3 animals undergo a necrotic-like death, not programmed cell death [4].

Anatomical context of mes-3

Phenotypic and molecular analysis of mes-3, a maternal-effect gene required for proliferation and viability of the germ line in C. elegans [4].

References

Depletion of a novel SET-domain protein enhances the sterility of mes-3 and mes-4 mutants of Caenorhabditis elegans. Xu, L., Strome, S. Genetics (2001) [Pubmed]
MES-2, a maternal protein essential for viability of the germline in Caenorhabditis elegans, is homologous to a Drosophila Polycomb group protein. Holdeman, R., Nehrt, S., Strome, S. Development (1998) [Pubmed]
Caenorhabditis elegans MES-3 is a target of GLD-1 and functions epigenetically in germline development. Xu, L., Paulsen, J., Yoo, Y., Goodwin, E.B., Strome, S. Genetics (2001) [Pubmed]
Phenotypic and molecular analysis of mes-3, a maternal-effect gene required for proliferation and viability of the germ line in C. elegans. Paulsen, J.E., Capowski, E.E., Strome, S. Genetics (1995) [Pubmed]

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